An accelerometry-based study of lower and upper limb tremor in Parkinson's disease

Blake K. Scanlon, Bonnie Levin, Daniel A. Nation, Heather L. Katzen, Alexandra Guevara-Salcedo, Carlos Singer, Spiridon Papapetropoulos

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Over the past two decades, several studies have aimed to quantify the kinetic properties of tremor with primary focus on the upper limbs. However, there is a lack of investigation into the properties of tremor in the lower limbs. The objective of this preliminary study was to investigate the properties of oscillatory movement, at rest and in posture, in both the upper and lower limbs of Parkinson's disease (PD) patients with clinically undetectable to modest rest/postural tremor and healthy controls. PD patients (N = 16) and controls (N = 8) were examined clinically by a movement disorders specialist and oscillatory movements in all four extremities were evaluated using a portable biaxial accelerometer. While tremor intensity and frequency did not differ between groups, the intraindividual variability of rest and postural tremor frequency in the dexterity-dominant lower limb was lower in people living with PD than in healthy adults. Additionally, rest tremor frequency was discrepant between upper and lower limbs in PD. Our work introduces the possibility that minute variations in lower limb movements, which are imperceptible upon expert clinical exam, can be used to differentiate a diseased sample from a healthy one. These preliminary findings suggest that additional work using objective tremor measurement may improve our understanding of lower limb motor dysfunction in PD and lead to the refinement of current, and the development of new, metrics to enhance early diagnosis, differential diagnosis, and symptom quantification.

Original languageEnglish
Pages (from-to)827-830
Number of pages4
JournalJournal of Clinical Neuroscience
Volume20
Issue number6
DOIs
StatePublished - Jun 1 2013

Fingerprint

Accelerometry
Tremor
Parkinson Disease
Lower Extremity
Movement Disorders
Posture
Upper Extremity
Early Diagnosis
Differential Diagnosis
Extremities

Keywords

  • Extremities
  • Intraindividual variability
  • Monitoring
  • Parkinson's disease
  • Physiologic
  • Tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

Cite this

An accelerometry-based study of lower and upper limb tremor in Parkinson's disease. / Scanlon, Blake K.; Levin, Bonnie; Nation, Daniel A.; Katzen, Heather L.; Guevara-Salcedo, Alexandra; Singer, Carlos; Papapetropoulos, Spiridon.

In: Journal of Clinical Neuroscience, Vol. 20, No. 6, 01.06.2013, p. 827-830.

Research output: Contribution to journalArticle

Scanlon, BK, Levin, B, Nation, DA, Katzen, HL, Guevara-Salcedo, A, Singer, C & Papapetropoulos, S 2013, 'An accelerometry-based study of lower and upper limb tremor in Parkinson's disease', Journal of Clinical Neuroscience, vol. 20, no. 6, pp. 827-830. https://doi.org/10.1016/j.jocn.2012.06.015
Scanlon, Blake K. ; Levin, Bonnie ; Nation, Daniel A. ; Katzen, Heather L. ; Guevara-Salcedo, Alexandra ; Singer, Carlos ; Papapetropoulos, Spiridon. / An accelerometry-based study of lower and upper limb tremor in Parkinson's disease. In: Journal of Clinical Neuroscience. 2013 ; Vol. 20, No. 6. pp. 827-830.
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