Abstract
Over the past two decades, several studies have aimed to quantify the kinetic properties of tremor with primary focus on the upper limbs. However, there is a lack of investigation into the properties of tremor in the lower limbs. The objective of this preliminary study was to investigate the properties of oscillatory movement, at rest and in posture, in both the upper and lower limbs of Parkinson's disease (PD) patients with clinically undetectable to modest rest/postural tremor and healthy controls. PD patients (N = 16) and controls (N = 8) were examined clinically by a movement disorders specialist and oscillatory movements in all four extremities were evaluated using a portable biaxial accelerometer. While tremor intensity and frequency did not differ between groups, the intraindividual variability of rest and postural tremor frequency in the dexterity-dominant lower limb was lower in people living with PD than in healthy adults. Additionally, rest tremor frequency was discrepant between upper and lower limbs in PD. Our work introduces the possibility that minute variations in lower limb movements, which are imperceptible upon expert clinical exam, can be used to differentiate a diseased sample from a healthy one. These preliminary findings suggest that additional work using objective tremor measurement may improve our understanding of lower limb motor dysfunction in PD and lead to the refinement of current, and the development of new, metrics to enhance early diagnosis, differential diagnosis, and symptom quantification.
| Original language | English |
|---|---|
| Pages (from-to) | 827-830 |
| Number of pages | 4 |
| Journal | Journal of Clinical Neuroscience |
| Volume | 20 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2013 |
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Keywords
- Extremities
- Intraindividual variability
- Monitoring
- Parkinson's disease
- Physiologic
- Tremor
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Physiology (medical)
- Medicine(all)
Cite this
An accelerometry-based study of lower and upper limb tremor in Parkinson's disease. / Scanlon, Blake K.; Levin, Bonnie; Nation, Daniel A.; Katzen, Heather L.; Guevara-Salcedo, Alexandra; Singer, Carlos; Papapetropoulos, Spiridon.
In: Journal of Clinical Neuroscience, Vol. 20, No. 6, 01.06.2013, p. 827-830.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An accelerometry-based study of lower and upper limb tremor in Parkinson's disease
AU - Scanlon, Blake K.
AU - Levin, Bonnie
AU - Nation, Daniel A.
AU - Katzen, Heather L.
AU - Guevara-Salcedo, Alexandra
AU - Singer, Carlos
AU - Papapetropoulos, Spiridon
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Over the past two decades, several studies have aimed to quantify the kinetic properties of tremor with primary focus on the upper limbs. However, there is a lack of investigation into the properties of tremor in the lower limbs. The objective of this preliminary study was to investigate the properties of oscillatory movement, at rest and in posture, in both the upper and lower limbs of Parkinson's disease (PD) patients with clinically undetectable to modest rest/postural tremor and healthy controls. PD patients (N = 16) and controls (N = 8) were examined clinically by a movement disorders specialist and oscillatory movements in all four extremities were evaluated using a portable biaxial accelerometer. While tremor intensity and frequency did not differ between groups, the intraindividual variability of rest and postural tremor frequency in the dexterity-dominant lower limb was lower in people living with PD than in healthy adults. Additionally, rest tremor frequency was discrepant between upper and lower limbs in PD. Our work introduces the possibility that minute variations in lower limb movements, which are imperceptible upon expert clinical exam, can be used to differentiate a diseased sample from a healthy one. These preliminary findings suggest that additional work using objective tremor measurement may improve our understanding of lower limb motor dysfunction in PD and lead to the refinement of current, and the development of new, metrics to enhance early diagnosis, differential diagnosis, and symptom quantification.
AB - Over the past two decades, several studies have aimed to quantify the kinetic properties of tremor with primary focus on the upper limbs. However, there is a lack of investigation into the properties of tremor in the lower limbs. The objective of this preliminary study was to investigate the properties of oscillatory movement, at rest and in posture, in both the upper and lower limbs of Parkinson's disease (PD) patients with clinically undetectable to modest rest/postural tremor and healthy controls. PD patients (N = 16) and controls (N = 8) were examined clinically by a movement disorders specialist and oscillatory movements in all four extremities were evaluated using a portable biaxial accelerometer. While tremor intensity and frequency did not differ between groups, the intraindividual variability of rest and postural tremor frequency in the dexterity-dominant lower limb was lower in people living with PD than in healthy adults. Additionally, rest tremor frequency was discrepant between upper and lower limbs in PD. Our work introduces the possibility that minute variations in lower limb movements, which are imperceptible upon expert clinical exam, can be used to differentiate a diseased sample from a healthy one. These preliminary findings suggest that additional work using objective tremor measurement may improve our understanding of lower limb motor dysfunction in PD and lead to the refinement of current, and the development of new, metrics to enhance early diagnosis, differential diagnosis, and symptom quantification.
KW - Extremities
KW - Intraindividual variability
KW - Monitoring
KW - Parkinson's disease
KW - Physiologic
KW - Tremor
UR - http://www.scopus.com/inward/record.url?scp=84891881118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891881118&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2012.06.015
DO - 10.1016/j.jocn.2012.06.015
M3 - Article
C2 - 23639618
AN - SCOPUS:84891881118
VL - 20
SP - 827
EP - 830
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
IS - 6
ER -