Amygdala and fusiform gyrus temporal dynamics: Responses to negative facial expressions

Jennifer C Britton, Lisa M. Shin, Lisa Barrett, Scott L. Rauch, Christopher I. Wright

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: The amygdala habituates in response to repeated human facial expressions; however, it is unclear whether this brain region habituates to schematic faces (i.e., simple line drawings or caricatures of faces). Using an fMRI block design, 16 healthy participants passively viewed repeated presentations of schematic and human neutral and negative facial expressions. Percent signal changes within anatomic regions-of-interest (amygdala and fusiform gyrus) were calculated to examine the temporal dynamics of neural response and any response differences based on face type. Results: The amygdala and fusiform gyrus had a within-run "U" response pattern of activity to facial expression blocks. The initial block within each run elicited the greatest activation (relative to baseline) and the final block elicited greater activation than the preceding block. No significant differences between schematic and human faces were detected in the amygdala or fusiform gyrus. Conclusion: The "U" pattern of response in the amygdala and fusiform gyrus to facial expressions suggests an initial orienting, habituation, and activation recovery in these regions. Furthermore, this study is the first to directly compare brain responses to schematic and human facial expressions, and the similarity in brain responses suggest that schematic faces may be useful in studying amygdala activation.

Original languageEnglish
Article number44
JournalBMC Neuroscience
Volume9
DOIs
StatePublished - May 12 2008
Externally publishedYes

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Facial Expression
Temporal Lobe
Amygdala
Brain
Caricatures
Healthy Volunteers
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Amygdala and fusiform gyrus temporal dynamics : Responses to negative facial expressions. / Britton, Jennifer C; Shin, Lisa M.; Barrett, Lisa; Rauch, Scott L.; Wright, Christopher I.

In: BMC Neuroscience, Vol. 9, 44, 12.05.2008.

Research output: Contribution to journalArticle

Britton, Jennifer C ; Shin, Lisa M. ; Barrett, Lisa ; Rauch, Scott L. ; Wright, Christopher I. / Amygdala and fusiform gyrus temporal dynamics : Responses to negative facial expressions. In: BMC Neuroscience. 2008 ; Vol. 9.
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