Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder

Jennifer C Britton, Evelyn Stewart, William D S Killgore, Isabelle M. Rosso, Lauren M. Price, Andrea L. Gold, Daniel S. Pine, Sabine Wilhelm, Michael A. Jenike, Scott L. Rauch

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation [Cannistraro et al. (2004). Biological Psychiatry 56:916-920]. Methods: In the current event-related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N512) and a HC sample (N517) performed a gender discrimination task while viewing emotional faces (happy, fearful, disgusted) and neutral faces. Results: Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. Conclusions: Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder specific. Depression and Anxiety 27:643-651, 2010.

Original languageEnglish
Pages (from-to)643-651
Number of pages9
JournalDepression and Anxiety
Volume27
Issue number7
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

Fingerprint

Facial Expression
Obsessive-Compulsive Disorder
Amygdala
Pediatrics
Anxiety Disorders
Biological Psychiatry
Hippocampus
Healthy Volunteers
Emotions
Anxiety
Magnetic Resonance Imaging
Depression

Keywords

  • Anxiety disorder
  • Disgust
  • Fear
  • FMRI
  • Neuroimaging
  • OCD

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Britton, J. C., Stewart, E., Killgore, W. D. S., Rosso, I. M., Price, L. M., Gold, A. L., ... Rauch, S. L. (2010). Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder. Depression and Anxiety, 27(7), 643-651. https://doi.org/10.1002/da.20718

Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder. / Britton, Jennifer C; Stewart, Evelyn; Killgore, William D S; Rosso, Isabelle M.; Price, Lauren M.; Gold, Andrea L.; Pine, Daniel S.; Wilhelm, Sabine; Jenike, Michael A.; Rauch, Scott L.

In: Depression and Anxiety, Vol. 27, No. 7, 01.07.2010, p. 643-651.

Research output: Contribution to journalArticle

Britton, JC, Stewart, E, Killgore, WDS, Rosso, IM, Price, LM, Gold, AL, Pine, DS, Wilhelm, S, Jenike, MA & Rauch, SL 2010, 'Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder', Depression and Anxiety, vol. 27, no. 7, pp. 643-651. https://doi.org/10.1002/da.20718
Britton, Jennifer C ; Stewart, Evelyn ; Killgore, William D S ; Rosso, Isabelle M. ; Price, Lauren M. ; Gold, Andrea L. ; Pine, Daniel S. ; Wilhelm, Sabine ; Jenike, Michael A. ; Rauch, Scott L. / Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder. In: Depression and Anxiety. 2010 ; Vol. 27, No. 7. pp. 643-651.
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