Amrinone, isoproterenol and ouabain modification of cardiac K+ contracture

Marion S. Gaide, Stephen P. Baker, Alan M. Ezrin, Henry Gelband, Arthur L. Bassett

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The effects of amrinone, a new cardiotonic bipyridine derivative, were compared to those isoproterenol and ouabain on maintained K+-induced contracture of isolated cat ventricualr muscle. Peak K+induced contracture force was decreased by amrinone (5.3 × 10-4 M) and isoproterenol (10-6 M), 31 ± 10% (n = 4, P ≤ 0.05) and 81 ± 5% (n = 4, P ≤ 0.05), respectively, and increased by ouabain (5.0 x 10-7 M), 60 ± 6% (n = 4, P ≤ 0.05). The effects of amrinone and ouabain on K+ contracture persisted during β-adrenergic blockade produced by nadolol (10- M) whereas isoproterenol's actions were attenuated. The effect of amrinone on K+-contracture force was concentration-related as was its modification of phasic isometric contractions (0.5 Hz). Resting tension, time to peak force and durection of isometric contraction were unchanged by amirone (5.3 × 10-6-1.6 × 10-3 M). Apparently, amrinone concomitantly Ca2+ release and sequestration or extrusion and thus the drug may not provoke cardiac toxicity by Ca2+ overload.

Original languageEnglish (US)
Pages (from-to)253-260
Number of pages8
JournalEuropean Journal of Pharmacology
Volume73
Issue number4
DOIs
StatePublished - Aug 14 1981

Keywords

  • Ca release
  • Isolated cat ventricular muscle
  • Isometric force Sequestration or extrusion
  • Nadolol
  • β-Receptor blockade

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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    Gaide, M. S., Baker, S. P., Ezrin, A. M., Gelband, H., & Bassett, A. L. (1981). Amrinone, isoproterenol and ouabain modification of cardiac K+ contracture. European Journal of Pharmacology, 73(4), 253-260. https://doi.org/10.1016/0014-2999(81)90225-9