Ampicillin prophylaxis in preterm premature rupture of the membranes: A prospective randomized study

E. Amon, S. V. Lewis, B. M. Sibai, M. A. Villar, Kristopher Arheart

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

It is hypothesized that ampicillin may treat subclinical deciduitis and prolong the 'effective' latent period in patients with preterm premature rupture of the membranes. We studied 82 patients with preterm rupture of membranes who were managed expectantly and were randomly assigned either to receive ampicillin prophylaxis (n = 43) or not to receive ampicillin prophylaxis (n = 39). Patients were excluded from study entry on admission if they had suspected or frank chorioamnionitis, active preterm labor, a history of penicillin allergy, multiple gestation, or cervical cerclage. There were no significant differences between the groups in duration of membrane rupture prior to admission, gestational age at membrane rupture, use of steroids and tocolysis, and demographic factors. Life-table analysis showed that the risk of delivery was significantly lower for the group of patients receiving prophylactic ampicillin. The incidence of neonatal infection was significantly lower in the ampicillin group, 1 (2%) versus 6 (17%), p < 0.04.

Original languageEnglish
Pages (from-to)539-543
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume159
Issue number3
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Ampicillin
Prospective Studies
Rupture
Membranes
Cervical Cerclage
Tocolysis
Chorioamnionitis
Life Tables
Premature Obstetric Labor
Penicillins
Gestational Age
Hypersensitivity
Steroids
Demography
Preterm Premature Rupture of the Membranes
Pregnancy
Incidence
Infection

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Ampicillin prophylaxis in preterm premature rupture of the membranes : A prospective randomized study. / Amon, E.; Lewis, S. V.; Sibai, B. M.; Villar, M. A.; Arheart, Kristopher.

In: American Journal of Obstetrics and Gynecology, Vol. 159, No. 3, 01.01.1988, p. 539-543.

Research output: Contribution to journalArticle

Amon, E. ; Lewis, S. V. ; Sibai, B. M. ; Villar, M. A. ; Arheart, Kristopher. / Ampicillin prophylaxis in preterm premature rupture of the membranes : A prospective randomized study. In: American Journal of Obstetrics and Gynecology. 1988 ; Vol. 159, No. 3. pp. 539-543.
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