Abstract
It is hypothesized that ampicillin may treat subclinical deciduitis and prolong the 'effective' latent period in patients with preterm premature rupture of the membranes. We studied 82 patients with preterm rupture of membranes who were managed expectantly and were randomly assigned either to receive ampicillin prophylaxis (n = 43) or not to receive ampicillin prophylaxis (n = 39). Patients were excluded from study entry on admission if they had suspected or frank chorioamnionitis, active preterm labor, a history of penicillin allergy, multiple gestation, or cervical cerclage. There were no significant differences between the groups in duration of membrane rupture prior to admission, gestational age at membrane rupture, use of steroids and tocolysis, and demographic factors. Life-table analysis showed that the risk of delivery was significantly lower for the group of patients receiving prophylactic ampicillin. The incidence of neonatal infection was significantly lower in the ampicillin group, 1 (2%) versus 6 (17%), p < 0.04.
| Original language | English |
|---|---|
| Pages (from-to) | 539-543 |
| Number of pages | 5 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 159 |
| Issue number | 3 |
| State | Published - Jan 1 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Ampicillin prophylaxis in preterm premature rupture of the membranes : A prospective randomized study. / Amon, E.; Lewis, S. V.; Sibai, B. M.; Villar, M. A.; Arheart, Kristopher.
In: American Journal of Obstetrics and Gynecology, Vol. 159, No. 3, 01.01.1988, p. 539-543.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ampicillin prophylaxis in preterm premature rupture of the membranes
T2 - A prospective randomized study
AU - Amon, E.
AU - Lewis, S. V.
AU - Sibai, B. M.
AU - Villar, M. A.
AU - Arheart, Kristopher
PY - 1988/1/1
Y1 - 1988/1/1
N2 - It is hypothesized that ampicillin may treat subclinical deciduitis and prolong the 'effective' latent period in patients with preterm premature rupture of the membranes. We studied 82 patients with preterm rupture of membranes who were managed expectantly and were randomly assigned either to receive ampicillin prophylaxis (n = 43) or not to receive ampicillin prophylaxis (n = 39). Patients were excluded from study entry on admission if they had suspected or frank chorioamnionitis, active preterm labor, a history of penicillin allergy, multiple gestation, or cervical cerclage. There were no significant differences between the groups in duration of membrane rupture prior to admission, gestational age at membrane rupture, use of steroids and tocolysis, and demographic factors. Life-table analysis showed that the risk of delivery was significantly lower for the group of patients receiving prophylactic ampicillin. The incidence of neonatal infection was significantly lower in the ampicillin group, 1 (2%) versus 6 (17%), p < 0.04.
AB - It is hypothesized that ampicillin may treat subclinical deciduitis and prolong the 'effective' latent period in patients with preterm premature rupture of the membranes. We studied 82 patients with preterm rupture of membranes who were managed expectantly and were randomly assigned either to receive ampicillin prophylaxis (n = 43) or not to receive ampicillin prophylaxis (n = 39). Patients were excluded from study entry on admission if they had suspected or frank chorioamnionitis, active preterm labor, a history of penicillin allergy, multiple gestation, or cervical cerclage. There were no significant differences between the groups in duration of membrane rupture prior to admission, gestational age at membrane rupture, use of steroids and tocolysis, and demographic factors. Life-table analysis showed that the risk of delivery was significantly lower for the group of patients receiving prophylactic ampicillin. The incidence of neonatal infection was significantly lower in the ampicillin group, 1 (2%) versus 6 (17%), p < 0.04.
UR - http://www.scopus.com/inward/record.url?scp=0023772908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023772908&partnerID=8YFLogxK
M3 - Article
C2 - 3421250
AN - SCOPUS:0023772908
VL - 159
SP - 539
EP - 543
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 3
ER -