Amphiphilic, PEG-based nanoparticles for the delivery of hydrophobic drugs

D. Missirlis, N. Tirelli, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The preparation and characterization of sub-micron hydrophilic nanoparticles with an ability to solubilize and release bioactive hydrophobic molecules in a controlled thermoset was reported. Pyrene fluorescence was studied in different nanoparticle concentrations to determine nanostructure. It was observed that the nanoparticle diameters, ranging between 50 and 500 nm, increased with the macromonomer concentration and with decreasing emulsifier content. The absorbance intensity at 490 nm of the nanoparticle suspension was used to calculate the percentage of doxorubicin (DOX) released.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Missirlis, D., Tirelli, N., & Hubbell, J. A. (2004). Amphiphilic, PEG-based nanoparticles for the delivery of hydrophobic drugs. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).