Amphiphilic hydrogel nanoparticles. Preparation, characterization, and preliminary assessment as new colloidal drug carriers

Dimitris Missirlis, Nicola Tirelli, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Inverse emulsion photopolymerization of acrylated poly(ethylene glycol)-bl-poly(propylene glycol)-bl-poly(ethylene glycol) and poly(ethylene glycol) was successfully employed to prepare stable, cross-linked, amphiphilic nanoparticles. Even at low emulsifier concentrations (2%) and high water-to-hexane weight ratios (35/65), the stability of the inverse emulsion allowed for the formation of well-defined colloidal material. Inverse emulsion characteristics and polymerization conditions could be controlled to vary the size of the nanoparticles between 50 and 500 nm. The presence of hydrophobic nanodomains within these otherwise hydrophilic nanoparticles was verified by using pyrene as a microenvironmentally sensitive probe. The hydrophobic poly(propylene glycol)-rich domains appear to be suitable for incorporation of hydrophobic drugs, encapsulating Doxorubicin up to 9.8% (w/w). We believe that the complex nano-architecture of these materials makes them a potentially interesting colloidal drug delivery carrier system and that the method should be useful for a number of amphiphilic macromolecular precursors.

Original languageEnglish
Pages (from-to)2605-2613
Number of pages9
JournalLangmuir
Volume21
Issue number6
DOIs
StatePublished - Mar 15 2005
Externally publishedYes

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Propylene Glycol
Drug Carriers
Hydrogel
Glycols
Hydrogels
Propylene
glycols
drugs
Nanoparticles
propylene
nanoparticles
preparation
Ethylene Glycol
Ethylene glycol
Emulsions
emulsions
ethylene
Photopolymerization
Pyrene
Hexanes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Amphiphilic hydrogel nanoparticles. Preparation, characterization, and preliminary assessment as new colloidal drug carriers. / Missirlis, Dimitris; Tirelli, Nicola; Hubbell, Jeffrey A.

In: Langmuir, Vol. 21, No. 6, 15.03.2005, p. 2605-2613.

Research output: Contribution to journalArticle

Missirlis, Dimitris ; Tirelli, Nicola ; Hubbell, Jeffrey A. / Amphiphilic hydrogel nanoparticles. Preparation, characterization, and preliminary assessment as new colloidal drug carriers. In: Langmuir. 2005 ; Vol. 21, No. 6. pp. 2605-2613.
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