Amphetamine activates an amine-gated chloride channel to generate behavioral effects in caenorhabditis elegans

Bryan D. Safratowich, Chee Lor, Laura Bianchi, Lucia Carvelli

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Amphetamine affects Caenorhabditis elegans behavior by acting on dopamine transporter (DAT) however residual effects are present in DAT knockouts. Results: DAT-independent behaviors are eliminated by knocking out the LGC-55 channels. Conclusion: Amphetamine mediates behavioral effects by acting on both DAT and LGC-55. Significance: The identification of a novel amphetamine target in C. elegans suggests alternative mechanisms underlying the effects of this psychostimulant.

Original languageEnglish (US)
Pages (from-to)21630-21637
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
StatePublished - Jul 26 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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