Amphetamine activates an amine-gated chloride channel to generate behavioral effects in caenorhabditis elegans

Bryan D. Safratowich; Chee Lor; Laura Bianchi; Lucia Carvelli

doi:10.1074/jbc.M113.484139

Amphetamine activates an amine-gated chloride channel to generate behavioral effects in caenorhabditis elegans

Bryan D. Safratowich, Chee Lor, Laura Bianchi, Lucia Carvelli

Physiology & Biophysics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Amphetamine affects Caenorhabditis elegans behavior by acting on dopamine transporter (DAT) however residual effects are present in DAT knockouts. Results: DAT-independent behaviors are eliminated by knocking out the LGC-55 channels. Conclusion: Amphetamine mediates behavioral effects by acting on both DAT and LGC-55. Significance: The identification of a novel amphetamine target in C. elegans suggests alternative mechanisms underlying the effects of this psychostimulant.

Original language	English (US)
Pages (from-to)	21630-21637
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.484139
State	Published - Jul 26 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: Amphetamine affects Caenorhabditis elegans behavior by acting on dopamine transporter (DAT) however residual effects are present in DAT knockouts. Results: DAT-independent behaviors are eliminated by knocking out the LGC-55 channels. Conclusion: Amphetamine mediates behavioral effects by acting on both DAT and LGC-55. Significance: The identification of a novel amphetamine target in C. elegans suggests alternative mechanisms underlying the effects of this psychostimulant.",

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AU - Safratowich, Bryan D.

AU - Lor, Chee

AU - Bianchi, Laura

AU - Carvelli, Lucia

PY - 2013/7/26

Y1 - 2013/7/26

N2 - Background: Amphetamine affects Caenorhabditis elegans behavior by acting on dopamine transporter (DAT) however residual effects are present in DAT knockouts. Results: DAT-independent behaviors are eliminated by knocking out the LGC-55 channels. Conclusion: Amphetamine mediates behavioral effects by acting on both DAT and LGC-55. Significance: The identification of a novel amphetamine target in C. elegans suggests alternative mechanisms underlying the effects of this psychostimulant.

AB - Background: Amphetamine affects Caenorhabditis elegans behavior by acting on dopamine transporter (DAT) however residual effects are present in DAT knockouts. Results: DAT-independent behaviors are eliminated by knocking out the LGC-55 channels. Conclusion: Amphetamine mediates behavioral effects by acting on both DAT and LGC-55. Significance: The identification of a novel amphetamine target in C. elegans suggests alternative mechanisms underlying the effects of this psychostimulant.

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Amphetamine activates an amine-gated chloride channel to generate behavioral effects in caenorhabditis elegans

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