Abstract
Background: Amphetamine affects Caenorhabditis elegans behavior by acting on dopamine transporter (DAT) however residual effects are present in DAT knockouts. Results: DAT-independent behaviors are eliminated by knocking out the LGC-55 channels. Conclusion: Amphetamine mediates behavioral effects by acting on both DAT and LGC-55. Significance: The identification of a novel amphetamine target in C. elegans suggests alternative mechanisms underlying the effects of this psychostimulant.
Original language | English (US) |
---|---|
Pages (from-to) | 21630-21637 |
Number of pages | 8 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 30 |
DOIs | |
State | Published - Jul 26 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology