Amoxapine was compared to imipramine and placebo in a double-blind four-week trial with depressed inpatients. The authors examined the quantities of 3-methoxy-4-hydroxyphenylglycol (MHPG) in the pretreatment urines. Although most patients felt improved, no significant difference was found in improvement or side effects based on doctor and self-rating scales. A consistently high correlation (r) was noted between pretreatment MHPG and response to imipramine but not to amoxapine. A different mechanism of action or diagnostic heterogeneity within treatment groups may account for this finding.
|Original language||English (US)|
|Number of pages||7|
|Journal||Current Therapeutic Research - Clinical and Experimental|
|State||Published - Jan 1 1979|
ASJC Scopus subject areas
- Pharmacology (medical)