Amoxapine, imipramine and placebo: A double-blind study with pretherapy urinary 3-methoxy-4-hydroxyphenylglycol levels

R. M. Steinbook, A. F. Jacobson, B. L. Weiss, B. J. Goldstein

Research output: Contribution to journalArticle

8 Scopus citations


Amoxapine was compared to imipramine and placebo in a double-blind four-week trial with depressed inpatients. The authors examined the quantities of 3-methoxy-4-hydroxyphenylglycol (MHPG) in the pretreatment urines. Although most patients felt improved, no significant difference was found in improvement or side effects based on doctor and self-rating scales. A consistently high correlation (r) was noted between pretreatment MHPG and response to imipramine but not to amoxapine. A different mechanism of action or diagnostic heterogeneity within treatment groups may account for this finding.

Original languageEnglish (US)
Pages (from-to)490-496
Number of pages7
JournalCurrent Therapeutic Research - Clinical and Experimental
Issue number5
StatePublished - Jan 1 1979


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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