Amniotic fluid-derived stem cells in regenerative medicine research

Sunyoung Joo, In Kap Ko, Anthony Atala, James J. Yoo, Sang Jin Lee

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

The stem cells isolated from amniotic fluid present an exciting possible contribution to the field of regenerative medicine and amniotic fluid-derived stem (AFS) cells have significant potential for research and therapeutic applications. AFS cells are multipotent, showing the ability to differentiate into cell types from all three embryonic germ layers. They express both embryonic and adult stem cell markers, expand extensively without feeder cells, double in 36 h, and are not tumorigenic. The AFS cells can be maintained for over 250 population doublings and preserve their telomere length and a normal karyotype. They differentiate easily into specific cell lineages and do not require human embryo tissue for their isolation, thus avoiding the current controversies associated with the use of human embryonic stem (ES) cells. The discovery of the AFS cells has been recent, and a great deal of work remains to be performed on the characterization and use of these cells. This review describes the various differentiated lineages that AFS cells can form and the future of these promising new stem cells in regenerative medicine research.

Original languageEnglish (US)
Pages (from-to)271-280
Number of pages10
JournalArchives of Pharmacal Research
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Amniotic fluid-derived stem (AFS) cells
  • Differentiation
  • Reconstruction
  • Regeneration
  • Regenerative medicine
  • Tissue engineering

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Organic Chemistry

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