Ammonia stimulates the release of taurine from cultured astrocytes

Jan Albrecht, Alex S. Bender, Michael D. Norenberg

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The effect of ammonia on the release of the neuroactive amino acids taurine (TAU), γ-aminobutyric acid (GABA) and d-aspartate (d-ASP), an analog of l-glutamate (l-GLU), from cultured rat cortical astrocytes was studied. NH4Cl (1 and 5 mM) induced the release of TAU. TAU release was reduced when Na+ was removed, and was almost completely abolished when Cl- was omitted. In contrast, TAU basal release was enhanced upon removal of Na+ or Cl-. Ammonia inhibited the release of GABA and d-ASP. Ammonia-induced release of astroglial TAU may modify the neuronal excitability accompanying hyperammonemic conditions.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalBrain Research
Volume660
Issue number2
DOIs
StatePublished - Oct 17 1994

Keywords

  • Amino acid release
  • Ammonium chloride
  • Astrocytes
  • GABA
  • Glutamate
  • Hepatic encephalopathy
  • Taurine

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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