Abstract
The effect of ammonia on the release of the neuroactive amino acids taurine (TAU), γ-aminobutyric acid (GABA) and d-aspartate (d-ASP), an analog of l-glutamate (l-GLU), from cultured rat cortical astrocytes was studied. NH4Cl (1 and 5 mM) induced the release of TAU. TAU release was reduced when Na+ was removed, and was almost completely abolished when Cl- was omitted. In contrast, TAU basal release was enhanced upon removal of Na+ or Cl-. Ammonia inhibited the release of GABA and d-ASP. Ammonia-induced release of astroglial TAU may modify the neuronal excitability accompanying hyperammonemic conditions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 288-292 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 660 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 17 1994 |
Keywords
- Amino acid release
- Ammonium chloride
- Astrocytes
- GABA
- Glutamate
- Hepatic encephalopathy
- Taurine
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Cite this
Albrecht, J., Bender, A. S., & Norenberg, M. D. (1994). Ammonia stimulates the release of taurine from cultured astrocytes. Brain Research, 660(2), 288-292. https://doi.org/10.1016/0006-8993(94)91301-3