This study was designed to investigate the role of opioid receptors, gamma-aminobutyric acid (GABA) receptors, mast cells and histamine receptors (H1 subtype) in the seizurogenic effect of amisulpride on mice. A single injection of amisulpride (180mg/kg) was employed to evaluate the seizurogenicity of the drug in mice. Seizures were assessed in terms of a composite seizure severity score (SSS), time of the onset of straub-like tail, onset of jerky movements of whole body, convulsions and death. Amisulpride administration (180mg/kg) induced a significant pro-convulsant effect in mice as measured in terms of the SSS (21.12±2.71) and a significant decrease in the time latency of the onset of straub-like tail (132.45±12.31), jerky movements of whole body (153.28±14.12), convulsions (184.97±13.11) and death (100%). Moreover, prior administration of naloxone, cetrizine, sodium cromoglycate and gabapentin, respectively, attenuated this seizurogenic activity that amisulpride exerted on mice (p<0.05). Therefore, it may be suggested that amisulpride exerts a seizurogenic effect on mice possibly via an opioid receptor activation-dependent release of histamine from the mast cells and a simultaneous inhibition of GABA release.
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