Amish study, IV: Genetic linkage study of pedigrees of bipolar probands

K. K. Kidd; J. A. Egeland; L. Molthan; D. L. Pauls; S. D. Kruger; K. H. Messner

doi:10.1176/ajp.141.9.1042

Amish study, IV: Genetic linkage study of pedigrees of bipolar probands

K. K. Kidd, J. A. Egeland, L. Molthan, D. L. Pauls, S. D. Kruger, K. H. Messner

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Genetic linkage studies were conducted on five Old Order Amish bipolar pedigrees in 1979 and 1982, with 94 members tested for color blindness and typed for 42 red blood cells and related markers in 17 antigen systems. Also, 59 individuals in two pedigrees were typed for HLA, Bf, and GLO. Linkage analyses assuming X-linkage and autosomal inheritance of bipolar illness were done with diagnostic schemes ranging from strict bipolar to milder forms of affective disorder. Linkage to affective disorders was not strongly supported for any marker locus. Close linkage to HLA was excluded, with weaker evidence against linkage to GLO.

Original language	English (US)
Pages (from-to)	1042-1048
Number of pages	7
Journal	American Journal of Psychiatry
Volume	141
Issue number	9
DOIs	https://doi.org/10.1176/ajp.141.9.1042
State	Published - Jan 1 1984

ASJC Scopus subject areas

Psychiatry and Mental health

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AU - Messner, K. H.

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