Amish study, IV: Genetic linkage study of pedigrees of bipolar probands

K. K. Kidd, J. A. Egeland, L. Molthan, D. L. Pauls, S. D. Kruger, K. H. Messner

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Genetic linkage studies were conducted on five Old Order Amish bipolar pedigrees in 1979 and 1982, with 94 members tested for color blindness and typed for 42 red blood cells and related markers in 17 antigen systems. Also, 59 individuals in two pedigrees were typed for HLA, Bf, and GLO. Linkage analyses assuming X-linkage and autosomal inheritance of bipolar illness were done with diagnostic schemes ranging from strict bipolar to milder forms of affective disorder. Linkage to affective disorders was not strongly supported for any marker locus. Close linkage to HLA was excluded, with weaker evidence against linkage to GLO.

Original languageEnglish (US)
Pages (from-to)1042-1048
Number of pages7
JournalAmerican Journal of Psychiatry
Volume141
Issue number9
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Psychiatry and Mental health

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