Aminophylline therapy for idiopathic apnea in premature infants: Effects on lung function

T. Gerhardt, J. McCarthy, E. Bancalari

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The effect of aminophylline on lung function was studied in 14 premature infants with apnea (gestational age, 30.2 wk; birth weight, 1,052 gm). The infants showed compromised pulmonary function with a large difference in alveolar-arterial PO2 gradient (83.9 mm Hg), a low normal lung compliance of 1.1 ml/cm H2O·kg, and a normal inspiratory resistance of 45.3 cm H20/liter/sec. Aminophylline therapy did not change these functions significantly, but it decreased the incidence of apneic episodes from 29.7 to 4.4 per day. The effectiveness of aminophylline in treating apnea in premature infants must be related to its central stimulating effect and not to an improvement in lung function and oxygenation.

Original languageEnglish (US)
Pages (from-to)801-804
Number of pages4
JournalPediatrics
Volume62
Issue number5
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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