Aminophylline-induced preictal alterations in cortical astrocytes

Michael D. Norenberg; Nai Shin Chu

doi:10.1016/0014-4886(77)90274-6

Aminophylline-induced preictal alterations in cortical astrocytes

Michael D. Norenberg, Nai Shin Chu

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A light and electron microscopic study was performed on rat cerebral cortex in the preictal state following the intraperitoneal injection of aminophylline. Morphological changes were observed only in astrocytes. The changes consisted chiefly of nuclear and cytoplasmic hydropic alterations, nuclear chromatin clumping, and a slight increase in cytoplasmic glycogen. It is suggested that astrocyte abnormalities may play a role in the pathogenesis of aminophylline-induced seizures.

Original language	English (US)
Pages (from-to)	340-351
Number of pages	12
Journal	Experimental neurology
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/0014-4886(77)90274-6
State	Published - Feb 1977
Externally published	Yes

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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title = "Aminophylline-induced preictal alterations in cortical astrocytes",

abstract = "A light and electron microscopic study was performed on rat cerebral cortex in the preictal state following the intraperitoneal injection of aminophylline. Morphological changes were observed only in astrocytes. The changes consisted chiefly of nuclear and cytoplasmic hydropic alterations, nuclear chromatin clumping, and a slight increase in cytoplasmic glycogen. It is suggested that astrocyte abnormalities may play a role in the pathogenesis of aminophylline-induced seizures.",

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