Aminophylline-induced preictal alterations in cortical astrocytes

Michael D. Norenberg, Nai Shin Chu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A light and electron microscopic study was performed on rat cerebral cortex in the preictal state following the intraperitoneal injection of aminophylline. Morphological changes were observed only in astrocytes. The changes consisted chiefly of nuclear and cytoplasmic hydropic alterations, nuclear chromatin clumping, and a slight increase in cytoplasmic glycogen. It is suggested that astrocyte abnormalities may play a role in the pathogenesis of aminophylline-induced seizures.

Original languageEnglish (US)
Pages (from-to)340-351
Number of pages12
JournalExperimental neurology
Issue number2
StatePublished - Feb 1977
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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