Abstract
A light and electron microscopic study was performed on rat cerebral cortex in the preictal state following the intraperitoneal injection of aminophylline. Morphological changes were observed only in astrocytes. The changes consisted chiefly of nuclear and cytoplasmic hydropic alterations, nuclear chromatin clumping, and a slight increase in cytoplasmic glycogen. It is suggested that astrocyte abnormalities may play a role in the pathogenesis of aminophylline-induced seizures.
| Original language | English |
|---|---|
| Pages (from-to) | 340-351 |
| Number of pages | 12 |
| Journal | Experimental Neurology |
| Volume | 54 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
Cite this
Aminophylline-induced preictal alterations in cortical astrocytes. / Norenberg, Michael D; Chu, Nai Shin.
In: Experimental Neurology, Vol. 54, No. 2, 01.01.1977, p. 340-351.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aminophylline-induced preictal alterations in cortical astrocytes
AU - Norenberg, Michael D
AU - Chu, Nai Shin
PY - 1977/1/1
Y1 - 1977/1/1
N2 - A light and electron microscopic study was performed on rat cerebral cortex in the preictal state following the intraperitoneal injection of aminophylline. Morphological changes were observed only in astrocytes. The changes consisted chiefly of nuclear and cytoplasmic hydropic alterations, nuclear chromatin clumping, and a slight increase in cytoplasmic glycogen. It is suggested that astrocyte abnormalities may play a role in the pathogenesis of aminophylline-induced seizures.
AB - A light and electron microscopic study was performed on rat cerebral cortex in the preictal state following the intraperitoneal injection of aminophylline. Morphological changes were observed only in astrocytes. The changes consisted chiefly of nuclear and cytoplasmic hydropic alterations, nuclear chromatin clumping, and a slight increase in cytoplasmic glycogen. It is suggested that astrocyte abnormalities may play a role in the pathogenesis of aminophylline-induced seizures.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017352359&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(77)90274-6
DO - 10.1016/0014-4886(77)90274-6
M3 - Article
C2 - 838022
AN - SCOPUS:0017352359
VL - 54
SP - 340
EP - 351
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 2
ER -