Aminophylline-induced preictal alterations in cortical astrocytes

Michael D Norenberg, Nai Shin Chu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A light and electron microscopic study was performed on rat cerebral cortex in the preictal state following the intraperitoneal injection of aminophylline. Morphological changes were observed only in astrocytes. The changes consisted chiefly of nuclear and cytoplasmic hydropic alterations, nuclear chromatin clumping, and a slight increase in cytoplasmic glycogen. It is suggested that astrocyte abnormalities may play a role in the pathogenesis of aminophylline-induced seizures.

Original languageEnglish
Pages (from-to)340-351
Number of pages12
JournalExperimental Neurology
Volume54
Issue number2
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

Fingerprint

Aminophylline
Astrocytes
Intraperitoneal Injections
Glycogen
Cerebral Cortex
Chromatin
Edema
Seizures
Electrons
Light

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Aminophylline-induced preictal alterations in cortical astrocytes. / Norenberg, Michael D; Chu, Nai Shin.

In: Experimental Neurology, Vol. 54, No. 2, 01.01.1977, p. 340-351.

Research output: Contribution to journalArticle

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