Abstract
Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild-type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 93-98 |
| Number of pages | 6 |
| Journal | FEMS Microbiology Letters |
| Volume | 206 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2 2002 |
| Externally published | Yes |
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Keywords
- Aminoguinidine
- iNOS knockout mouse
- Salmonella typhimurium
ASJC Scopus subject areas
- Microbiology
- Molecular Biology
- Genetics
Cite this
Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection. / Zhou, Xin; Potoka, Douglas A.; Boyle, Patricia; Nadler, Evan P.; McGinnis, Kathleen; Ford, Henri.
In: FEMS Microbiology Letters, Vol. 206, No. 1, 02.01.2002, p. 93-98.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection
AU - Zhou, Xin
AU - Potoka, Douglas A.
AU - Boyle, Patricia
AU - Nadler, Evan P.
AU - McGinnis, Kathleen
AU - Ford, Henri
PY - 2002/1/2
Y1 - 2002/1/2
N2 - Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild-type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.
AB - Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild-type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.
KW - Aminoguinidine
KW - iNOS knockout mouse
KW - Salmonella typhimurium
UR - http://www.scopus.com/inward/record.url?scp=0037005876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037005876&partnerID=8YFLogxK
U2 - 10.1016/S0378-1097(01)00539-0
DO - 10.1016/S0378-1097(01)00539-0
M3 - Article
C2 - 11786263
AN - SCOPUS:0037005876
VL - 206
SP - 93
EP - 98
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
SN - 0378-1097
IS - 1
ER -