Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection

Xin Zhou; Douglas A. Potoka; Patricia Boyle; Evan P. Nadler; Kathleen McGinnis; Henri R. Ford

doi:10.1016/S0378-1097(01)00539-0

Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection

Xin Zhou, Douglas A. Potoka, Patricia Boyle, Evan P. Nadler, Kathleen McGinnis, Henri R. Ford

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild-type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.

Original language	English (US)
Pages (from-to)	93-98
Number of pages	6
Journal	FEMS microbiology letters
Volume	206
Issue number	1
DOIs	https://doi.org/10.1016/S0378-1097(01)00539-0
State	Published - Jan 2 2002

Keywords

Aminoguinidine
Salmonella typhimurium
iNOS knockout mouse

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

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title = "Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection",

abstract = "Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild-type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.",

keywords = "Aminoguinidine, Salmonella typhimurium, iNOS knockout mouse",

author = "Xin Zhou and Potoka, {Douglas A.} and Patricia Boyle and Nadler, {Evan P.} and Kathleen McGinnis and Ford, {Henri R.}",

note = "Funding Information: This work was supported by Grant #RO1-AI-14032 from the National Institutes of Health, Bethesda, MD, USA, the faculty startup fund for X.Z. and the Benjamin R. Fisher Endowed Chair in Pediatric Surgery. We thank Xiao R. Zhang for technical assistance.",

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T1 - Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection

AU - Zhou, Xin

AU - Potoka, Douglas A.

AU - Boyle, Patricia

AU - Nadler, Evan P.

AU - McGinnis, Kathleen

AU - Ford, Henri R.

N1 - Funding Information: This work was supported by Grant #RO1-AI-14032 from the National Institutes of Health, Bethesda, MD, USA, the faculty startup fund for X.Z. and the Benjamin R. Fisher Endowed Chair in Pediatric Surgery. We thank Xiao R. Zhang for technical assistance.

PY - 2002/1/2

Y1 - 2002/1/2

N2 - Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild-type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.

AB - Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild-type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.

KW - Aminoguinidine

KW - Salmonella typhimurium

KW - iNOS knockout mouse

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