Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection

Xin Zhou, Douglas A. Potoka, Patricia Boyle, Evan P. Nadler, Kathleen McGinnis, Henri R. Ford

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS has been reported to play an important role in host defense against S. typhimurium infection both in vitro and in vivo. In this report we show those AG treatment lead to weight loss in both wild-type and iNOS knockout mice, and rendered them more susceptible to Salmonella infection. These results suggest that AG may have side effects other than the inhibition of iNOS, and that data obtained from studies using AG should be interpreted with caution.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalFEMS microbiology letters
Volume206
Issue number1
DOIs
StatePublished - Jan 2 2002
Externally publishedYes

Keywords

  • Aminoguinidine
  • Salmonella typhimurium
  • iNOS knockout mouse

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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