Aminoglycoside mediated ototoxicity and hearing loss in cystic fibrosis patients: An unmet medical need

Rahul Mittal, Luca H. Debs, Kalai Mathee

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cystic Fibrosis (CF) is a highly debaliting disease that occurs with high prevalence worldwide. Due to the frequent infections observed in CF patients, physicians recommend antibiotics especially aminoglycosides. However, it leads to cochlear ototoxicity and consequent hearing loss in CF patients. In this commentary, we have highlighted the serious issue of aminoglycoside mediated hearing loss in CF patients. Through this commentary, we want to draw the attention of the clinicians that an active collaboration between pulmonologists and otolaryngologists will facilitate in early detection of hearing loss in CF patients and hence better clinical outcomes. We have also discussed the alternative approaches to avoid aminoglycoside-induced cochleotoxicity in CF patients.

Original languageEnglish (US)
Title of host publicationOtotoxicity
Subtitle of host publicationSigns, Symptoms and Treatment
PublisherNova Science Publishers, Inc.
Pages149-154
Number of pages6
ISBN (Electronic)9781536164176
ISBN (Print)9781536163964
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Medicine(all)

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