Amino acid release by isolated perfused cirrhotic livers

Guido Perez, Barbara Rietberg, Eugene R Schiff

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Livers of normal and cirrhotic rats were perfused in vitro with and without amino acid substrates (2.3 mM ornithine, 10 mM glutamine or 20 mM alanine) in order to assess urea formation and amino acid release. The rates of urea production were lower in the livers of cirrhotic rats when compared to those of controls only in perfusions with added substrates. The release of several amino acids by livers of cirrhotic rats was higher than that of controls although the pattern of amino acids in the perfusate was different from that reported in plasma during hepatic insufficiency.

Original languageEnglish
Pages (from-to)2533-2537
Number of pages5
JournalLife Sciences
Volume23
Issue number25
DOIs
StatePublished - Dec 18 1978

Fingerprint

Liver
Rats
Amino Acids
Urea
Hepatic Insufficiency
Ornithine
Substrates
Glutamine
Alanine
Perfusion
Plasmas

ASJC Scopus subject areas

  • Pharmacology

Cite this

Amino acid release by isolated perfused cirrhotic livers. / Perez, Guido; Rietberg, Barbara; Schiff, Eugene R.

In: Life Sciences, Vol. 23, No. 25, 18.12.1978, p. 2533-2537.

Research output: Contribution to journalArticle

Perez, Guido ; Rietberg, Barbara ; Schiff, Eugene R. / Amino acid release by isolated perfused cirrhotic livers. In: Life Sciences. 1978 ; Vol. 23, No. 25. pp. 2533-2537.
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