Abstract
Livers of normal and cirrhotic rats were perfused in vitro with and without amino acid substrates (2.3 mM ornithine, 10 mM glutamine or 20 mM alanine) in order to assess urea formation and amino acid release. The rates of urea production were lower in the livers of cirrhotic rats when compared to those of controls only in perfusions with added substrates. The release of several amino acids by livers of cirrhotic rats was higher than that of controls although the pattern of amino acids in the perfusate was different from that reported in plasma during hepatic insufficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 2533-2537 |
| Number of pages | 5 |
| Journal | Life Sciences |
| Volume | 23 |
| Issue number | 25 |
| DOIs | |
| State | Published - Dec 18 1978 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology
Cite this
Amino acid release by isolated perfused cirrhotic livers. / Perez, Guido; Rietberg, Barbara; Schiff, Eugene R.
In: Life Sciences, Vol. 23, No. 25, 18.12.1978, p. 2533-2537.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amino acid release by isolated perfused cirrhotic livers
AU - Perez, Guido
AU - Rietberg, Barbara
AU - Schiff, Eugene R
PY - 1978/12/18
Y1 - 1978/12/18
N2 - Livers of normal and cirrhotic rats were perfused in vitro with and without amino acid substrates (2.3 mM ornithine, 10 mM glutamine or 20 mM alanine) in order to assess urea formation and amino acid release. The rates of urea production were lower in the livers of cirrhotic rats when compared to those of controls only in perfusions with added substrates. The release of several amino acids by livers of cirrhotic rats was higher than that of controls although the pattern of amino acids in the perfusate was different from that reported in plasma during hepatic insufficiency.
AB - Livers of normal and cirrhotic rats were perfused in vitro with and without amino acid substrates (2.3 mM ornithine, 10 mM glutamine or 20 mM alanine) in order to assess urea formation and amino acid release. The rates of urea production were lower in the livers of cirrhotic rats when compared to those of controls only in perfusions with added substrates. The release of several amino acids by livers of cirrhotic rats was higher than that of controls although the pattern of amino acids in the perfusate was different from that reported in plasma during hepatic insufficiency.
UR - http://www.scopus.com/inward/record.url?scp=0018236307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018236307&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(78)90180-7
DO - 10.1016/0024-3205(78)90180-7
M3 - Article
C2 - 732539
AN - SCOPUS:0018236307
VL - 23
SP - 2533
EP - 2537
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 25
ER -