Amino acid release by isolated perfused cirrhotic livers

Guido Perez, Barbara Rietberg, Eugene Schiff

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Livers of normal and cirrhotic rats were perfused in vitro with and without amino acid substrates (2.3 mM ornithine, 10 mM glutamine or 20 mM alanine) in order to assess urea formation and amino acid release. The rates of urea production were lower in the livers of cirrhotic rats when compared to those of controls only in perfusions with added substrates. The release of several amino acids by livers of cirrhotic rats was higher than that of controls although the pattern of amino acids in the perfusate was different from that reported in plasma during hepatic insufficiency.

Original languageEnglish (US)
Pages (from-to)2533-2537
Number of pages5
JournalLife Sciences
Volume23
Issue number25
DOIs
StatePublished - Dec 18 1978

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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