Amino acid acceptor activity of tRNA-C-C-C-A

Arthur H. Kirschenbaum, Murray P. Deutscher

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Rabbit liver tRNA nucleotidyltransferase was used to synthesize modified tRNA molecules containing an additional CMP residue at the 3′ terminus. In the first step tRNA-C-C was converted to tRNA-C-C-C by a minor activity of the purified enzyme. In the second step the lengthened molecules were converted to tRNA-C-C-C-A. AMP addition to tRNA-C-C-C occurred at about 50% the rate with tRNA-C-C. Aminoacylation studies indicated that tRNA-C-C-C-A was active for acceptance of at least 12 amino acids.

Original languageEnglish (US)
Pages (from-to)258-264
Number of pages7
JournalBiochemical and biophysical research communications
Volume70
Issue number1
DOIs
StatePublished - May 3 1976

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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