Amantadine-induced peripheral neuropathy

Lisa M. Shulman, Alireza Minagar, Khema Sharma, William J. Weiner

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We report a 48-year-old woman with a 17-year history of PD who developed a peripheral sensory-motor neuropathy secondary to chronic administration (8 years) of amantadine. Discontinuation of amantadine resulted in resolution of trophic skin ulcers, paresthesias, and distal weakness. Amantadine may be hazardous to patients with severe and chronic livedo reticularis.

Original languageEnglish (US)
Pages (from-to)1862-1865
Number of pages4
Issue number8
StatePublished - Nov 10 1999


  • Amantadine
  • PD
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)


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