Alzheimer's-disease-related protein in geriatric schizophrenic patients with cognitive impairment

Peter Powchik, Michael Davidson, Charles B. Nemeroff, Vahram Haroutunian, Dushyant Purohit, Miklos Losonczy, Garth Bissette, Daniel Perl, Hossein Ghanbari, Barney Miller, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The authors compared Alz-50 immunoreactivity in the brain tissue of nine cognitively impaired elderly schizophrenic patients and 13 elderly comparison subjects, both without neuritic plaques or neurofibrillary tangles, and 13 patients with Alzheimer's disease. Alz-50 reactivity was absent in the schizophrenic patients, indicating that geriatric, cognitively impaired patients are unlikely to display the pathology of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)1726-1727
Number of pages2
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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