Abstract
Growing evidence suggests that hypertension and Alzheimers disease (AD) may share a common etiology. To evaluate the contribution to AD of genetic factors associated with hypertension, we genotyped clinic and community-based AD cases and controls for polymorphisms within the pancreatic PLA2 gene and the G protein β3 subunit gene, both of which are located on chromosome 12. Our results do not support an independent association between either of these genes and AD. We further assessed the possibility that either of these genes may interact with the apolipoprotein E gene, a known risk factor for hypertension and AD, on predicting AD. We were unable to find statistical interaction between either the pancreatic PLA2 or Gβ3 genes and the apolipoprotein E gene on risk for AD. These results do not support a shared genetic etiology between hypertension and AD. Possibly, a clinical association between these diseases could be due to pathophysiologic interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 465-468 |
| Number of pages | 4 |
| Journal | American Journal of Medical Genetics - Neuropsychiatric Genetics |
| Volume | 88 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 15 1999 |
| Externally published | Yes |
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Keywords
- Alzheimers disease
- Chromosome 12
- G protein
- Hypertension
- Phospholipase A
ASJC Scopus subject areas
- Genetics(clinical)
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
Cite this
Alzheimers disease is not associated with the hypertension genetic risk factors PLA2 or G protein β3, either independently or interactively with apolipoprotein E. / Town, Terrence; Paris, Daniel; Parker, Timothy A.; Kundtz, Amy; Tan, Jun; Duara, Ranjan; Gold, Michael; Crawford, Fiona; Mullan, Michael.
In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 88, No. 5, 15.10.1999, p. 465-468.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alzheimers disease is not associated with the hypertension genetic risk factors PLA2 or G protein β3, either independently or interactively with apolipoprotein E
AU - Town, Terrence
AU - Paris, Daniel
AU - Parker, Timothy A.
AU - Kundtz, Amy
AU - Tan, Jun
AU - Duara, Ranjan
AU - Gold, Michael
AU - Crawford, Fiona
AU - Mullan, Michael
PY - 1999/10/15
Y1 - 1999/10/15
N2 - Growing evidence suggests that hypertension and Alzheimers disease (AD) may share a common etiology. To evaluate the contribution to AD of genetic factors associated with hypertension, we genotyped clinic and community-based AD cases and controls for polymorphisms within the pancreatic PLA2 gene and the G protein β3 subunit gene, both of which are located on chromosome 12. Our results do not support an independent association between either of these genes and AD. We further assessed the possibility that either of these genes may interact with the apolipoprotein E gene, a known risk factor for hypertension and AD, on predicting AD. We were unable to find statistical interaction between either the pancreatic PLA2 or Gβ3 genes and the apolipoprotein E gene on risk for AD. These results do not support a shared genetic etiology between hypertension and AD. Possibly, a clinical association between these diseases could be due to pathophysiologic interactions.
AB - Growing evidence suggests that hypertension and Alzheimers disease (AD) may share a common etiology. To evaluate the contribution to AD of genetic factors associated with hypertension, we genotyped clinic and community-based AD cases and controls for polymorphisms within the pancreatic PLA2 gene and the G protein β3 subunit gene, both of which are located on chromosome 12. Our results do not support an independent association between either of these genes and AD. We further assessed the possibility that either of these genes may interact with the apolipoprotein E gene, a known risk factor for hypertension and AD, on predicting AD. We were unable to find statistical interaction between either the pancreatic PLA2 or Gβ3 genes and the apolipoprotein E gene on risk for AD. These results do not support a shared genetic etiology between hypertension and AD. Possibly, a clinical association between these diseases could be due to pathophysiologic interactions.
KW - Alzheimers disease
KW - Chromosome 12
KW - G protein
KW - Hypertension
KW - Phospholipase A
UR - http://www.scopus.com/inward/record.url?scp=0033569785&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033569785&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8628(19991015)88:5<465::AID-AJMG5>3.0.CO;2-M
DO - 10.1002/(SICI)1096-8628(19991015)88:5<465::AID-AJMG5>3.0.CO;2-M
M3 - Article
C2 - 10490699
AN - SCOPUS:0033569785
VL - 88
SP - 465
EP - 468
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 5
ER -