Alzheimers disease is not associated with the hypertension genetic risk factors PLA2 or G protein β3, either independently or interactively with apolipoprotein E

Terrence Town, Daniel Paris, Timothy A. Parker, Amy Kundtz, Jun Tan, Ranjan Duara, Michael Gold, Fiona Crawford, Michael Mullan

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Growing evidence suggests that hypertension and Alzheimers disease (AD) may share a common etiology. To evaluate the contribution to AD of genetic factors associated with hypertension, we genotyped clinic and community-based AD cases and controls for polymorphisms within the pancreatic PLA2 gene and the G protein β3 subunit gene, both of which are located on chromosome 12. Our results do not support an independent association between either of these genes and AD. We further assessed the possibility that either of these genes may interact with the apolipoprotein E gene, a known risk factor for hypertension and AD, on predicting AD. We were unable to find statistical interaction between either the pancreatic PLA2 or Gβ3 genes and the apolipoprotein E gene on risk for AD. These results do not support a shared genetic etiology between hypertension and AD. Possibly, a clinical association between these diseases could be due to pathophysiologic interactions.

Original languageEnglish (US)
Pages (from-to)465-468
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume88
Issue number5
DOIs
StatePublished - Oct 15 1999

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Keywords

  • Alzheimers disease
  • Chromosome 12
  • G protein
  • Hypertension
  • Phospholipase A

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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