Alzheimer II astrocytosis following methionine sulfoximine

J. A. Gutierrez, Michael D Norenberg

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A light microscopic study was performed during the preictal period following the administration of methionine sulfoximine (MSO) to adult rats. The principal morphologic observation was the development of Alzheimer II astrocytes in gray matter, suggesting that the metabolic abnormality induced by MSO is initially confined to the astrocyte. In view of the association of the Alzheimer II astrocyte with hyperammonemic states, the drug toxicity may be secondary to the presence of ammonia. A possible mechanism involves astrocytes in the development of seizures produced by MSO.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalArchives of Neurology
Volume32
Issue number2
StatePublished - Jan 1 1975
Externally publishedYes

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Methionine Sulfoximine
Gliosis
Astrocytes
Drug-Related Side Effects and Adverse Reactions
Ammonia
Seizures
Observation
Light
Alzheimer

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alzheimer II astrocytosis following methionine sulfoximine. / Gutierrez, J. A.; Norenberg, Michael D.

In: Archives of Neurology, Vol. 32, No. 2, 01.01.1975, p. 123-126.

Research output: Contribution to journalArticle

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