Alveolar soft-part sarcoma of the female genital tract: A report of nine cases and review of the literature

G. P. Nielsen, E. Oliva, R. H. Young, Andrew Rosenberg, G. R. Dickersin, R. E. Scully

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Nine alveolar soft-part sarcomas of the female genital tract (four previously reported) occurred in patients 14-38 (mean 29) years of age. The most common clinical presentation was abnormal uterine bleeding. Two tumors were located in the vagina, three in the cervix or lower uterine segment, three in the uterine corpus, and one in the broad ligament. The tumors were solid and well circumscribed, ranging in maximum dimension from 1 to 9.8 (average 3.6) cm and had the characteristic histologic features of alveolar soft-part sarcoma. Granules that were diastase resistant and positive by periodic acid-Schiff (PAS) were present in all the tumors, and PAS-positive, diastase-resistant crystals were present in eight of them. Follow-up information ranging from 9 months to 17 years (average 62 months) was available for all the patients. One patient died of metastatic disease 25 months after diagnosis; eight other patients had uneventful follow-up periods ranging from 9 months to 17 years (average 67 months). The differential diagnosis of these tumors is discussed and the literature reviewed.

Original languageEnglish
Pages (from-to)283-292
Number of pages10
JournalInternational Journal of Gynecological Pathology
Volume14
Issue number4
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Alveolar Soft Part Sarcoma
Periodic Acid
Amylases
Neoplasms
Broad Ligament
Uterine Hemorrhage
Vagina
Cervix Uteri
Differential Diagnosis

Keywords

  • Alveolar soft-part sarcoma
  • Broad ligament
  • Cervix
  • Uterus
  • Vagina

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pathology and Forensic Medicine

Cite this

Alveolar soft-part sarcoma of the female genital tract : A report of nine cases and review of the literature. / Nielsen, G. P.; Oliva, E.; Young, R. H.; Rosenberg, Andrew; Dickersin, G. R.; Scully, R. E.

In: International Journal of Gynecological Pathology, Vol. 14, No. 4, 01.01.1995, p. 283-292.

Research output: Contribution to journalArticle

Nielsen, G. P. ; Oliva, E. ; Young, R. H. ; Rosenberg, Andrew ; Dickersin, G. R. ; Scully, R. E. / Alveolar soft-part sarcoma of the female genital tract : A report of nine cases and review of the literature. In: International Journal of Gynecological Pathology. 1995 ; Vol. 14, No. 4. pp. 283-292.
@article{32e9b5f0991443fb9ac0c986e1ee3bb4,
title = "Alveolar soft-part sarcoma of the female genital tract: A report of nine cases and review of the literature",
abstract = "Nine alveolar soft-part sarcomas of the female genital tract (four previously reported) occurred in patients 14-38 (mean 29) years of age. The most common clinical presentation was abnormal uterine bleeding. Two tumors were located in the vagina, three in the cervix or lower uterine segment, three in the uterine corpus, and one in the broad ligament. The tumors were solid and well circumscribed, ranging in maximum dimension from 1 to 9.8 (average 3.6) cm and had the characteristic histologic features of alveolar soft-part sarcoma. Granules that were diastase resistant and positive by periodic acid-Schiff (PAS) were present in all the tumors, and PAS-positive, diastase-resistant crystals were present in eight of them. Follow-up information ranging from 9 months to 17 years (average 62 months) was available for all the patients. One patient died of metastatic disease 25 months after diagnosis; eight other patients had uneventful follow-up periods ranging from 9 months to 17 years (average 67 months). The differential diagnosis of these tumors is discussed and the literature reviewed.",
keywords = "Alveolar soft-part sarcoma, Broad ligament, Cervix, Uterus, Vagina",
author = "Nielsen, {G. P.} and E. Oliva and Young, {R. H.} and Andrew Rosenberg and Dickersin, {G. R.} and Scully, {R. E.}",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "14",
pages = "283--292",
journal = "International Journal of Gynecological Pathology",
issn = "0277-1691",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Alveolar soft-part sarcoma of the female genital tract

T2 - A report of nine cases and review of the literature

AU - Nielsen, G. P.

AU - Oliva, E.

AU - Young, R. H.

AU - Rosenberg, Andrew

AU - Dickersin, G. R.

AU - Scully, R. E.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Nine alveolar soft-part sarcomas of the female genital tract (four previously reported) occurred in patients 14-38 (mean 29) years of age. The most common clinical presentation was abnormal uterine bleeding. Two tumors were located in the vagina, three in the cervix or lower uterine segment, three in the uterine corpus, and one in the broad ligament. The tumors were solid and well circumscribed, ranging in maximum dimension from 1 to 9.8 (average 3.6) cm and had the characteristic histologic features of alveolar soft-part sarcoma. Granules that were diastase resistant and positive by periodic acid-Schiff (PAS) were present in all the tumors, and PAS-positive, diastase-resistant crystals were present in eight of them. Follow-up information ranging from 9 months to 17 years (average 62 months) was available for all the patients. One patient died of metastatic disease 25 months after diagnosis; eight other patients had uneventful follow-up periods ranging from 9 months to 17 years (average 67 months). The differential diagnosis of these tumors is discussed and the literature reviewed.

AB - Nine alveolar soft-part sarcomas of the female genital tract (four previously reported) occurred in patients 14-38 (mean 29) years of age. The most common clinical presentation was abnormal uterine bleeding. Two tumors were located in the vagina, three in the cervix or lower uterine segment, three in the uterine corpus, and one in the broad ligament. The tumors were solid and well circumscribed, ranging in maximum dimension from 1 to 9.8 (average 3.6) cm and had the characteristic histologic features of alveolar soft-part sarcoma. Granules that were diastase resistant and positive by periodic acid-Schiff (PAS) were present in all the tumors, and PAS-positive, diastase-resistant crystals were present in eight of them. Follow-up information ranging from 9 months to 17 years (average 62 months) was available for all the patients. One patient died of metastatic disease 25 months after diagnosis; eight other patients had uneventful follow-up periods ranging from 9 months to 17 years (average 67 months). The differential diagnosis of these tumors is discussed and the literature reviewed.

KW - Alveolar soft-part sarcoma

KW - Broad ligament

KW - Cervix

KW - Uterus

KW - Vagina

UR - http://www.scopus.com/inward/record.url?scp=0029079874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029079874&partnerID=8YFLogxK

M3 - Article

C2 - 8598329

AN - SCOPUS:0029079874

VL - 14

SP - 283

EP - 292

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

SN - 0277-1691

IS - 4

ER -