Abstract
Primary astrocyte cultures derived from neonatal rat cerebral cortex were treated for 5 min with 0.5 mM or 5.0 mM AlCl3, and the incubation medium was analyzed by HPLC for the content of released glutamate (Glu), taurine (Tau), serine (Ser) and the nucleoside adenosine (Ade). At 0.5 mM, AlCl3 stimulated Tau release to about 170% of basal levels, but did not affect the release of the other compounds. Treatment with 5.0 mM AlCl3 enhanced the release of Tau, Glu and Ade, to 800%, 1000% and 250%, respectively, but decreased the release of Ser to 70% compared to basal levels. The enhanced release of these neuroactive compounds from astrocytes may contribute to changes in neural transmission known to accompany exposure to aluminum.
| Original language | English |
|---|---|
| Pages (from-to) | 105-107 |
| Number of pages | 3 |
| Journal | Neuroscience Letters |
| Volume | 127 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jun 10 1991 |
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Keywords
- Aluminum toxicity
- Cerebral cortex
- Cultured astrocyte
- Taurine
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Aluminum chloride stimulates the release of endogenous glutamate, taurine and adenosine from cultured rat cortical astrocytes. / Albrecht, Jan; Simmons, Martha; Dutton, Gary R.; Norenberg, Michael D.
In: Neuroscience Letters, Vol. 127, No. 1, 10.06.1991, p. 105-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aluminum chloride stimulates the release of endogenous glutamate, taurine and adenosine from cultured rat cortical astrocytes
AU - Albrecht, Jan
AU - Simmons, Martha
AU - Dutton, Gary R.
AU - Norenberg, Michael D
PY - 1991/6/10
Y1 - 1991/6/10
N2 - Primary astrocyte cultures derived from neonatal rat cerebral cortex were treated for 5 min with 0.5 mM or 5.0 mM AlCl3, and the incubation medium was analyzed by HPLC for the content of released glutamate (Glu), taurine (Tau), serine (Ser) and the nucleoside adenosine (Ade). At 0.5 mM, AlCl3 stimulated Tau release to about 170% of basal levels, but did not affect the release of the other compounds. Treatment with 5.0 mM AlCl3 enhanced the release of Tau, Glu and Ade, to 800%, 1000% and 250%, respectively, but decreased the release of Ser to 70% compared to basal levels. The enhanced release of these neuroactive compounds from astrocytes may contribute to changes in neural transmission known to accompany exposure to aluminum.
AB - Primary astrocyte cultures derived from neonatal rat cerebral cortex were treated for 5 min with 0.5 mM or 5.0 mM AlCl3, and the incubation medium was analyzed by HPLC for the content of released glutamate (Glu), taurine (Tau), serine (Ser) and the nucleoside adenosine (Ade). At 0.5 mM, AlCl3 stimulated Tau release to about 170% of basal levels, but did not affect the release of the other compounds. Treatment with 5.0 mM AlCl3 enhanced the release of Tau, Glu and Ade, to 800%, 1000% and 250%, respectively, but decreased the release of Ser to 70% compared to basal levels. The enhanced release of these neuroactive compounds from astrocytes may contribute to changes in neural transmission known to accompany exposure to aluminum.
KW - Aluminum toxicity
KW - Cerebral cortex
KW - Cultured astrocyte
KW - Taurine
UR - http://www.scopus.com/inward/record.url?scp=0025922307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025922307&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(91)90905-9
DO - 10.1016/0304-3940(91)90905-9
M3 - Article
VL - 127
SP - 105
EP - 107
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -