Aluminum chloride stimulates the release of endogenous glutamate, taurine and adenosine from cultured rat cortical astrocytes

Jan Albrecht, Martha Simmons, Gary R. Dutton, Michael D. Norenberg

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Primary astrocyte cultures derived from neonatal rat cerebral cortex were treated for 5 min with 0.5 mM or 5.0 mM AlCl3, and the incubation medium was analyzed by HPLC for the content of released glutamate (Glu), taurine (Tau), serine (Ser) and the nucleoside adenosine (Ade). At 0.5 mM, AlCl3 stimulated Tau release to about 170% of basal levels, but did not affect the release of the other compounds. Treatment with 5.0 mM AlCl3 enhanced the release of Tau, Glu and Ade, to 800%, 1000% and 250%, respectively, but decreased the release of Ser to 70% compared to basal levels. The enhanced release of these neuroactive compounds from astrocytes may contribute to changes in neural transmission known to accompany exposure to aluminum.

Original languageEnglish (US)
Pages (from-to)105-107
Number of pages3
JournalNeuroscience Letters
Volume127
Issue number1
DOIs
StatePublished - Jun 10 1991

    Fingerprint

Keywords

  • Aluminum toxicity
  • Cerebral cortex
  • Cultured astrocyte
  • Taurine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this