Abstract
Although intensive insulin therapy has resulted in improved metabolic control and decreases in the incidence of complications, the occurrence of severe hypoglycemia remains an issue, as does the continued potential for complications. Islet transplantation, a promising treatment for type I diabetes, has been shown to improve blood sugar levels and decrease or even abrogate the incidence of hypoglycemia. The lack of tissue availability and the toxic effects of immunosuppressants, however, limit the application of islet transplantation as a cure for diabetes. This article discusses possible alternatives to immunosuppressive drugs in human islet transplantations.
| Original language | English |
|---|---|
| Pages (from-to) | 377-382 |
| Number of pages | 6 |
| Journal | Curr Diab Rep |
| Volume | 2 |
| Issue number | 4 |
| State | Published - Aug 1 2002 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine
Cite this
Alternatives to immunosuppressive drugs in human islet transplantation. / Cotterell, Alison Anne; Kenyon, Norma S.
In: Curr Diab Rep, Vol. 2, No. 4, 01.08.2002, p. 377-382.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alternatives to immunosuppressive drugs in human islet transplantation.
AU - Cotterell, Alison Anne
AU - Kenyon, Norma S
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Although intensive insulin therapy has resulted in improved metabolic control and decreases in the incidence of complications, the occurrence of severe hypoglycemia remains an issue, as does the continued potential for complications. Islet transplantation, a promising treatment for type I diabetes, has been shown to improve blood sugar levels and decrease or even abrogate the incidence of hypoglycemia. The lack of tissue availability and the toxic effects of immunosuppressants, however, limit the application of islet transplantation as a cure for diabetes. This article discusses possible alternatives to immunosuppressive drugs in human islet transplantations.
AB - Although intensive insulin therapy has resulted in improved metabolic control and decreases in the incidence of complications, the occurrence of severe hypoglycemia remains an issue, as does the continued potential for complications. Islet transplantation, a promising treatment for type I diabetes, has been shown to improve blood sugar levels and decrease or even abrogate the incidence of hypoglycemia. The lack of tissue availability and the toxic effects of immunosuppressants, however, limit the application of islet transplantation as a cure for diabetes. This article discusses possible alternatives to immunosuppressive drugs in human islet transplantations.
UR - http://www.scopus.com/inward/record.url?scp=0036706714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036706714&partnerID=8YFLogxK
M3 - Article
C2 - 12643199
AN - SCOPUS:0036706714
VL - 2
SP - 377
EP - 382
JO - Current Diabetes Reports
JF - Current Diabetes Reports
SN - 1534-4827
IS - 4
ER -