Alternatives to immunosuppressive drugs in human islet transplantation.

Alison Anne Cotterell, Norma Sue Kenyon

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Although intensive insulin therapy has resulted in improved metabolic control and decreases in the incidence of complications, the occurrence of severe hypoglycemia remains an issue, as does the continued potential for complications. Islet transplantation, a promising treatment for type I diabetes, has been shown to improve blood sugar levels and decrease or even abrogate the incidence of hypoglycemia. The lack of tissue availability and the toxic effects of immunosuppressants, however, limit the application of islet transplantation as a cure for diabetes. This article discusses possible alternatives to immunosuppressive drugs in human islet transplantations.

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalCurrent diabetes reports
Volume2
Issue number4
DOIs
StatePublished - Aug 2002

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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