Alternative splicing of RAGE: Roles in biology and disease

Anastasia Z. Kalea, Ann Marie Schmidt, Barry I. Hudson

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


The Receptor for Advanced Glycation End-products (RAGE) is a complex, multi-ligand signaling system implicated in the pathogenesis of diabetes, cardiovascular disease and various cancers. RAGE undergoes extensive alternative splicing to produce a variety of transcripts with diverse functions, including soluble antagonists and variants with altered ligand binding domains. Studies focused on the major soluble variant (RAGEv1/esRAGE) have revealed this to function by binding RAGE-ligands and preventing activation of RAGE signaling in vascular and tumor cells. Furthermore, measurement of this variant in human serum has revealed that RAGEv1/esRAGE levels may represent a novel biomarker for RAGE-ligand related pathogenic states. Understanding the full plethora of RAGE alternative splicing and its regulation is central to elucidating the role of RAGE in biology and disease.

Original languageEnglish (US)
Pages (from-to)2756-2770
Number of pages15
JournalFrontiers in Bioscience
Issue number7
StatePublished - Jun 1 2011


  • Advanced Glycation End-products
  • Alternative splicing
  • mRNA
  • Receptors
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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