Alternative management of circumscribed choroidal hemangioma using intravitreal metoprolol

Rodrigo Jorge, Leandro Chaves, Armando da Silva Cunha, Zelia M. Correa

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background/Purpose: To describe a patient with visually symptomatic circumscribed choroidal hemangioma (CCH) treated successfully with intravitreal beta‐blocker. Methods: This is an interventional single case report of a 63 year‐old man with a juxtafoveal CCH and extensive subretinal fluid (SRF) unsuccessfully treated with intravitreal anti‐VEGF. Off‐label intravitreal use of metoprolol (50mg/0.05 ml) was then performed. Main outcome measures were resolution or decreased subretinal fluid on OCT, visual stability or improvement, lack of retinal/ocular toxicity. Results: Following 2 intravitreal injections of metoprolol (1 month apart), significant response was observed with decrease of SRF and visual improvement to 20/400 during a 9‐week follow‐up after the injections. Conclusion: These preliminary findings suggest that intravitreal metoprolol can be a safe alternative treatment for patients with CCH. This off‐label therapy could represent another option for patients with this condition.

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalRetinal Cases and Brief Reports
Issue number1
StatePublished - Jan 1 2022
Externally publishedYes


  • B-blocker
  • Choroidal hemangioma
  • Intravitreal
  • Retina
  • Subretinal fluid

ASJC Scopus subject areas

  • Ophthalmology


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