Altering the gut microbiome to potentially modulate behavioral manifestations in autism spectrum disorders: A systematic review

Camron Davies, Dibyanshi Mishra, Rebecca S. Eshraghi, Jeenu Mittal, Rahul Sinha, Erdogan Bulut, Rahul Mittal, Adrien A. Eshraghi

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

There is a potential association between gastrointestinal (GI) symptoms and the severity of autism spectrum disorder (ASD). Given this correlation, the possible impact of probiotics and prebiotics have been explored in research studies to modify the gut microbiome and ameliorate behavioral manifestations of ASD via modulating the gut-brain-microbiome axis. This systematic review focuses on the interplay between these factors in altering the behavioral manifestations of ASD. Probiotic supplementation tended to mitigate some of the behavioral manifestations of ASD, with less of a discernible trend on the microbiome level. Studies supplementing multiple probiotic species, such as microbiota transfer therapy, or including prebiotics performed better than single strain supplementation. Our analysis suggests that gut dysbiosis may increase intestinal permeability, leading to more severe GI symptoms and a systemic inflammatory response, which can alter permeability across the blood-brain barrier and synaptogenesis in the brain. Future studies are warranted to understand the precise contribution of altering gut microbiome on clinical manifestations of ASD that will open up avenues to develop preventive and treatment modalities.

Original languageEnglish (US)
Pages (from-to)549-557
Number of pages9
JournalNeuroscience and Biobehavioral Reviews
Volume128
DOIs
StatePublished - Sep 2021

Keywords

  • Autism spectrum disorders
  • Behavioral manifestations
  • Gastrointestinal problems
  • Gut microbiota
  • Gut-brain axis
  • Prebiotics
  • Probiotics

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'Altering the gut microbiome to potentially modulate behavioral manifestations in autism spectrum disorders: A systematic review'. Together they form a unique fingerprint.

Cite this