Altered pituitary hormone response to naloxone in hypertension development

James A. McCubbin; Richard S. Surwit; Redford B. Williams; Charles B. Nemeroff; Maya McNeilly

doi:10.1161/01.HYP.14.6.636

Altered pituitary hormone response to naloxone in hypertension development

James A. McCubbin, Richard S. Surwit, Redford B. Williams, Charles B. Nemeroff, Maya McNeilly

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.

Original language	English (US)
Pages (from-to)	636-644
Number of pages	9
Journal	Hypertension
Volume	14
Issue number	6
DOIs	https://doi.org/10.1161/01.HYP.14.6.636
State	Published - Dec 1989
Externally published	Yes

Keywords

β-endorphin
adrenocorticotropic hormone
blood pressure
essential hypertension
glucocorticoids
naloxone
opioids
stress

ASJC Scopus subject areas

Internal Medicine

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10.1161/01.HYP.14.6.636

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title = "Altered pituitary hormone response to naloxone in hypertension development",

abstract = "Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.",

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AU - Nemeroff, Charles B.

AU - McNeilly, Maya

PY - 1989/12

Y1 - 1989/12

N2 - Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.

AB - Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.

KW - β-endorphin

KW - adrenocorticotropic hormone

KW - blood pressure

KW - essential hypertension

KW - glucocorticoids

KW - naloxone

KW - opioids

KW - stress

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Altered pituitary hormone response to naloxone in hypertension development

Abstract

Keywords

ASJC Scopus subject areas

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