Abstract
Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.
| Original language | English |
|---|---|
| Pages (from-to) | 636-644 |
| Number of pages | 9 |
| Journal | Hypertension |
| Volume | 14 |
| Issue number | 6 |
| State | Published - Dec 1 1989 |
| Externally published | Yes |
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Keywords
- β-endorphin
- adrenocorticotropic hormone
- blood pressure
- essential hypertension
- glucocorticoids
- naloxone
- opioids
- stress
ASJC Scopus subject areas
- Internal Medicine
Cite this
Altered pituitary hormone response to naloxone in hypertension development. / McCubbin, J. A.; Surwit, R. S.; Williams, R. B.; Nemeroff, Charles; McNeilly, M.
In: Hypertension, Vol. 14, No. 6, 01.12.1989, p. 636-644.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered pituitary hormone response to naloxone in hypertension development
AU - McCubbin, J. A.
AU - Surwit, R. S.
AU - Williams, R. B.
AU - Nemeroff, Charles
AU - McNeilly, M.
PY - 1989/12/1
Y1 - 1989/12/1
N2 - Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.
AB - Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.
KW - β-endorphin
KW - adrenocorticotropic hormone
KW - blood pressure
KW - essential hypertension
KW - glucocorticoids
KW - naloxone
KW - opioids
KW - stress
UR - http://www.scopus.com/inward/record.url?scp=0024785649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024785649&partnerID=8YFLogxK
M3 - Article
C2 - 2555303
AN - SCOPUS:0024785649
VL - 14
SP - 636
EP - 644
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 6
ER -