Altered pituitary hormone response to naloxone in hypertension development

J. A. McCubbin, R. S. Surwit, R. B. Williams, Charles Nemeroff, M. McNeilly

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.

Original languageEnglish
Pages (from-to)636-644
Number of pages9
JournalHypertension
Volume14
Issue number6
StatePublished - Dec 1 1989
Externally publishedYes

Fingerprint

Pituitary Hormones
Naloxone
Endorphins
Hypertension
Adrenocorticotropic Hormone
Young Adult
Narcotic Antagonists
Psychological Stress
Hypotension
Opioid Analgesics
Arterial Pressure
Blood Pressure
Control Groups

Keywords

  • β-endorphin
  • adrenocorticotropic hormone
  • blood pressure
  • essential hypertension
  • glucocorticoids
  • naloxone
  • opioids
  • stress

ASJC Scopus subject areas

  • Internal Medicine

Cite this

McCubbin, J. A., Surwit, R. S., Williams, R. B., Nemeroff, C., & McNeilly, M. (1989). Altered pituitary hormone response to naloxone in hypertension development. Hypertension, 14(6), 636-644.

Altered pituitary hormone response to naloxone in hypertension development. / McCubbin, J. A.; Surwit, R. S.; Williams, R. B.; Nemeroff, Charles; McNeilly, M.

In: Hypertension, Vol. 14, No. 6, 01.12.1989, p. 636-644.

Research output: Contribution to journalArticle

McCubbin, JA, Surwit, RS, Williams, RB, Nemeroff, C & McNeilly, M 1989, 'Altered pituitary hormone response to naloxone in hypertension development', Hypertension, vol. 14, no. 6, pp. 636-644.
McCubbin JA, Surwit RS, Williams RB, Nemeroff C, McNeilly M. Altered pituitary hormone response to naloxone in hypertension development. Hypertension. 1989 Dec 1;14(6):636-644.
McCubbin, J. A. ; Surwit, R. S. ; Williams, R. B. ; Nemeroff, Charles ; McNeilly, M. / Altered pituitary hormone response to naloxone in hypertension development. In: Hypertension. 1989 ; Vol. 14, No. 6. pp. 636-644.
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