Altered pituitary hormone response to naloxone in hypertension development

James A. McCubbin, Richard S. Surwit, Redford B. Williams, Charles B. Nemeroff, Maya McNeilly

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and β-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and β-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.

Original languageEnglish (US)
Pages (from-to)636-644
Number of pages9
Issue number6
StatePublished - Dec 1989
Externally publishedYes


  • β-endorphin
  • adrenocorticotropic hormone
  • blood pressure
  • essential hypertension
  • glucocorticoids
  • naloxone
  • opioids
  • stress

ASJC Scopus subject areas

  • Internal Medicine


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