Altered mechanics of tibial cartilage following joint immobilization in a canine model

Lori A. Setton, Charles H. Perry, Michelle A. LeRoux, Jean Y. Wang, David S. Howell, Herman S. Cheung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


To study the effect of immobilization, the compressive and shear properties of articular cartilage were quantified at sites corresponding to those of elevated MMP staining on the tibial plateau of mongrel dogs. Cartilage samples were tested in compression and torsion on a displacement-controlled rheometer. The samples were weighed after testing and again after lyophilization to determine water content as the percentage of tissue wet weight. The results support the hypothesis that knee joint immobilization will produce deleterious changes in cartilage function at the tibial plateau.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Number of pages2
ISBN (Print)0791816117
StatePublished - 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999


Other1999 Bioengineering Conference
CityBig Sky, MT, USA

ASJC Scopus subject areas

  • Engineering(all)


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