Altered in vitro immune responses in green turtles (Chelonia mydas) with fibropapillomatosis

Carolyn Cray, Rene Varella, Gregory D. Bossart, Peter Lutz

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


The immune competence of green sea turtles (Chelonia mydas) with fibropapillomatosis was assessed using in vitro techniques to measure lymphocyte proliferation in response to mitogens. In comparison with captive, healthy green sea turtles, those afflicted with fibropapillomas demonstrated diminished proliferation with Concanavalin A, phytohemagglutinin (T-cell mitogens), and lipopolysaccharide (B-cell mitogen). Also, markedly decreased proliferative responses to the lymphocyte polyclonal stimulator combination of ionomycin and phorbol myristate acetate were observed. Total circulating white blood cell counts were not statistically different between the two groups, although an overall decrease in lymphocyte number was observed in the papilloma group. The albumin/globulin ratio was decreased in the papilloma group because of decreased albumin and increased gamma globulins.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
JournalJournal of Zoo and Wildlife Medicine
Issue number4
StatePublished - Jan 1 2001


  • Chelonia mydas
  • Fibropapillomatosis
  • Immune system
  • Mitogen
  • Reptile
  • Sea turtle

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Environmental Science(all)
  • veterinary(all)


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