Altered dopaminergic transmission in the anorexic anx/anx mouse striatum

Jeanette E. Johansen, Vera Lucas Teixeira, Carolina Johansson, Paula Serrão, Per Olof Berggren, Patricio Soares-Da-Silva, Martin Schalling, Alejandro M. Bertorello

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.

Original languageEnglish (US)
Pages (from-to)2737-2741
Number of pages5
JournalNeuroreport
Volume12
Issue number12
DOIs
StatePublished - Aug 28 2001

Keywords

  • Na,K-ATPase
  • Norepinephrine
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

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    Johansen, J. E., Teixeira, V. L., Johansson, C., Serrão, P., Berggren, P. O., Soares-Da-Silva, P., Schalling, M., & Bertorello, A. M. (2001). Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. Neuroreport, 12(12), 2737-2741. https://doi.org/10.1097/00001756-200108280-00029