Abstract
We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2737-2741 |
| Number of pages | 5 |
| Journal | Neuroreport |
| Volume | 12 |
| Issue number | 12 |
| DOIs | |
| State | Published - Aug 28 2001 |
Keywords
- Na,K-ATPase
- Norepinephrine
- Tyrosine hydroxylase
ASJC Scopus subject areas
- Neuroscience(all)
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Johansen, J. E., Teixeira, V. L., Johansson, C., Serrão, P., Berggren, P. O., Soares-Da-Silva, P., Schalling, M., & Bertorello, A. M. (2001). Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. Neuroreport, 12(12), 2737-2741. https://doi.org/10.1097/00001756-200108280-00029