Abstract
We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.
| Original language | English |
|---|---|
| Pages (from-to) | 2737-2741 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 12 |
| Issue number | 12 |
| State | Published - Aug 28 2001 |
| Externally published | Yes |
Fingerprint
Keywords
- Na,K-ATPase
- Norepinephrine
- Tyrosine hydroxylase
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. / Johansen, Jeanette E.; Teixeira, Vera Lucas; Johansson, Carolina; Serrão, Paula; Berggren, Per Olof; Soares-Da-Silva, Patricio; Schalling, Martin; Bertorello, Alejandro M.
In: NeuroReport, Vol. 12, No. 12, 28.08.2001, p. 2737-2741.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered dopaminergic transmission in the anorexic anx/anx mouse striatum
AU - Johansen, Jeanette E.
AU - Teixeira, Vera Lucas
AU - Johansson, Carolina
AU - Serrão, Paula
AU - Berggren, Per Olof
AU - Soares-Da-Silva, Patricio
AU - Schalling, Martin
AU - Bertorello, Alejandro M.
PY - 2001/8/28
Y1 - 2001/8/28
N2 - We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.
AB - We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.
KW - Na,K-ATPase
KW - Norepinephrine
KW - Tyrosine hydroxylase
UR - http://www.scopus.com/inward/record.url?scp=0035964371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035964371&partnerID=8YFLogxK
M3 - Article
C2 - 11522958
AN - SCOPUS:0035964371
VL - 12
SP - 2737
EP - 2741
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 12
ER -