TY - JOUR
T1 - Altered dopaminergic transmission in the anorexic anx/anx mouse striatum
AU - Johansen, Jeanette E.
AU - Teixeira, Vera Lucas
AU - Johansson, Carolina
AU - Serrão, Paula
AU - Berggren, Per Olof
AU - Soares-Da-Silva, Patricio
AU - Schalling, Martin
AU - Bertorello, Alejandro M.
PY - 2001/8/28
Y1 - 2001/8/28
N2 - We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.
AB - We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.
KW - Na,K-ATPase
KW - Norepinephrine
KW - Tyrosine hydroxylase
UR - http://www.scopus.com/inward/record.url?scp=0035964371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035964371&partnerID=8YFLogxK
U2 - 10.1097/00001756-200108280-00029
DO - 10.1097/00001756-200108280-00029
M3 - Article
C2 - 11522958
AN - SCOPUS:0035964371
VL - 12
SP - 2737
EP - 2741
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 12
ER -