Altered dopaminergic transmission in the anorexic anx/anx mouse striatum

Jeanette E. Johansen; Vera Lucas Teixeira; Carolina Johansson; Paula Serrão; Per Olof Berggren; Patricio Soares-Da-Silva; Martin Schalling; Alejandro M. Bertorello

doi:10.1097/00001756-200108280-00029

Altered dopaminergic transmission in the anorexic anx/anx mouse striatum

Jeanette E. Johansen, Vera Lucas Teixeira, Carolina Johansson, Paula Serrão, Per Olof Berggren, Patricio Soares-Da-Silva, Martin Schalling, Alejandro M. Bertorello

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Abstract

We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na⁺,K⁺-ATPase compared with normal littermates. Dopamine down-regulates Na⁺,K⁺-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.

Original language	English (US)
Pages (from-to)	2737-2741
Number of pages	5
Journal	Neuroreport
Volume	12
Issue number	12
DOIs	https://doi.org/10.1097/00001756-200108280-00029
State	Published - Aug 28 2001

Keywords

Na,K-ATPase
Norepinephrine
Tyrosine hydroxylase

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200108280-00029

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Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. / Johansen, Jeanette E.; Teixeira, Vera Lucas; Johansson, Carolina; Serrão, Paula; Berggren, Per Olof; Soares-Da-Silva, Patricio; Schalling, Martin; Bertorello, Alejandro M.

In: Neuroreport, Vol. 12, No. 12, 28.08.2001, p. 2737-2741.

Research output: Contribution to journal › Article › peer-review

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AU - Teixeira, Vera Lucas

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AU - Serrão, Paula

AU - Berggren, Per Olof

AU - Soares-Da-Silva, Patricio

AU - Schalling, Martin

AU - Bertorello, Alejandro M.

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AB - We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.

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Altered dopaminergic transmission in the anorexic anx/anx mouse striatum

Abstract

Keywords

ASJC Scopus subject areas

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