Altered dopaminergic transmission in the anorexic anx/anx mouse striatum

Jeanette E. Johansen, Vera Lucas Teixeira, Carolina Johansson, Paula Serrão, Per Olof Berggren, Patricio Soares-Da-Silva, Martin Schalling, Alejandro M. Bertorello

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype.

Original languageEnglish
Pages (from-to)2737-2741
Number of pages5
JournalNeuroReport
Volume12
Issue number12
StatePublished - Aug 28 2001
Externally publishedYes

Fingerprint

Corpus Striatum
Dopamine
Neurons
Starvation
Synaptic Transmission
Norepinephrine
Guinea Pigs
Down-Regulation
Phenotype
Mutation
sodium-translocating ATPase

Keywords

  • Na,K-ATPase
  • Norepinephrine
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Johansen, J. E., Teixeira, V. L., Johansson, C., Serrão, P., Berggren, P. O., Soares-Da-Silva, P., ... Bertorello, A. M. (2001). Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. NeuroReport, 12(12), 2737-2741.

Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. / Johansen, Jeanette E.; Teixeira, Vera Lucas; Johansson, Carolina; Serrão, Paula; Berggren, Per Olof; Soares-Da-Silva, Patricio; Schalling, Martin; Bertorello, Alejandro M.

In: NeuroReport, Vol. 12, No. 12, 28.08.2001, p. 2737-2741.

Research output: Contribution to journalArticle

Johansen, JE, Teixeira, VL, Johansson, C, Serrão, P, Berggren, PO, Soares-Da-Silva, P, Schalling, M & Bertorello, AM 2001, 'Altered dopaminergic transmission in the anorexic anx/anx mouse striatum', NeuroReport, vol. 12, no. 12, pp. 2737-2741.
Johansen JE, Teixeira VL, Johansson C, Serrão P, Berggren PO, Soares-Da-Silva P et al. Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. NeuroReport. 2001 Aug 28;12(12):2737-2741.
Johansen, Jeanette E. ; Teixeira, Vera Lucas ; Johansson, Carolina ; Serrão, Paula ; Berggren, Per Olof ; Soares-Da-Silva, Patricio ; Schalling, Martin ; Bertorello, Alejandro M. / Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. In: NeuroReport. 2001 ; Vol. 12, No. 12. pp. 2737-2741.
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