Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease

Adriana Zingone, Weixin Wang, Meghan Corrigan-Cummins, S. Peter Wu, Ryan Plyler, Neha Korde, Mary Kwok, Elisabet E. Manasanch, Nishant Tageja, Manisha Bhutani, Marcia Mulquin, Diamond Zuchlinski, Mary Ann Yancey, Mark Roschewski, Yong Zhang, Aldo M. Roccaro, Irene M. Ghobrial, Katherine R. Calvo, Ola Landgren

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Currently, no reliable biomarkers are available to predict transformation from smoldering myeloma (SMM) to multiple myeloma (MM). Using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) we assessed the levels of a broad range of cytokines and chemokines in the peripheral blood (PB) and bone marrow (BM) supernatant collected from 14 SMM and 38 MM patients and compared to healthy donors. We found significantly increased levels of key cytokines, in particular CXCL8 (IL-8), associated with progressive disease state (controls → SMM → MM). Cytokine profiles were found similar in PB and BM. Five of fourteen SMM patients (36%) progressed to MM.Our findings, although based on a limited number of patients, suggest that serum-based cytokines may have a future role as biomarkers for disease progression and could potentially be assessed as novel targets for treatment.

Original languageEnglish (US)
Pages (from-to)294-297
Number of pages4
JournalCytokine
Volume69
Issue number2
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Keywords

  • Chemokines
  • CXCL8
  • Multiple myeloma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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