Abstract
Objective: We aimed to assess whether migraine is associated with changes in the distribution of the venous drainage through primary and secondary pathways by using phase-contrast magnetic resonance imaging (MRI). Methods: We examined 26 patients (37.3 ± 13.9 years) with recurring migraine headaches and 26 age-and gender-matched controls with no neurologic disease (37.3 ± 13.7 years) on a 3 Tesla MR scanner. A 2D time-of-flight MR-venography of the upper neck region was performed to visualize the venous vasculature. Cine-phase contrast scans with highvelocity encoding were employed to quantify arterial inflow and flow in the primary venous channels (right and left jugular veins), whereas scans with low-velocity encoding were employed to quantify flow in the secondary venous channels (epidural, vertebral, and deep cervical veins). Results: Patients with migraine showed (i) a higher prevalence of dense secondary extracranial venous networks (15 vs. 2, P = 0.00002) and (ii) a significantly larger percentage of venous outflow through secondary channels (10.5% vs. 5.5%; of total cerebral blood flow, P = 0.02). This mainly included drainage through epidural, vertebral, and deep cervical veins. Conclusion: Migraine patients showed a significantly larger percentage of venous outflow through secondary channels. The mechanism of this alteration remains to be elucidated. Potential mechanisms include repeated release of vasoactive substances or growth factors.
| Original language | English |
|---|---|
| Pages (from-to) | 434-440 |
| Number of pages | 7 |
| Journal | Investigative Radiology |
| Volume | 46 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2011 |
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Keywords
- Migraine
- Phase-contrast imaging
- Secondary venous channels
- Total cerebral blood flow
- Venous outflow
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Altered cerebrovenous drainage in patients with migraine as assessed by phase-contrast magnetic resonance imaging. / Koerte, Inga K.; Schankin, Christoph J.; Immler, Stefanie; Lee, Sang; Laubender, Ruediger P.; Grosse, Christina; Eftimov, Lara; Milde-Busch, Astrid; Reiser, Maximilian; Straube, Andreas; Heinen, Florian; Alperin, Noam; Ertl-Wagner, Birgit.
In: Investigative Radiology, Vol. 46, No. 7, 01.07.2011, p. 434-440.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered cerebrovenous drainage in patients with migraine as assessed by phase-contrast magnetic resonance imaging
AU - Koerte, Inga K.
AU - Schankin, Christoph J.
AU - Immler, Stefanie
AU - Lee, Sang
AU - Laubender, Ruediger P.
AU - Grosse, Christina
AU - Eftimov, Lara
AU - Milde-Busch, Astrid
AU - Reiser, Maximilian
AU - Straube, Andreas
AU - Heinen, Florian
AU - Alperin, Noam
AU - Ertl-Wagner, Birgit
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Objective: We aimed to assess whether migraine is associated with changes in the distribution of the venous drainage through primary and secondary pathways by using phase-contrast magnetic resonance imaging (MRI). Methods: We examined 26 patients (37.3 ± 13.9 years) with recurring migraine headaches and 26 age-and gender-matched controls with no neurologic disease (37.3 ± 13.7 years) on a 3 Tesla MR scanner. A 2D time-of-flight MR-venography of the upper neck region was performed to visualize the venous vasculature. Cine-phase contrast scans with highvelocity encoding were employed to quantify arterial inflow and flow in the primary venous channels (right and left jugular veins), whereas scans with low-velocity encoding were employed to quantify flow in the secondary venous channels (epidural, vertebral, and deep cervical veins). Results: Patients with migraine showed (i) a higher prevalence of dense secondary extracranial venous networks (15 vs. 2, P = 0.00002) and (ii) a significantly larger percentage of venous outflow through secondary channels (10.5% vs. 5.5%; of total cerebral blood flow, P = 0.02). This mainly included drainage through epidural, vertebral, and deep cervical veins. Conclusion: Migraine patients showed a significantly larger percentage of venous outflow through secondary channels. The mechanism of this alteration remains to be elucidated. Potential mechanisms include repeated release of vasoactive substances or growth factors.
AB - Objective: We aimed to assess whether migraine is associated with changes in the distribution of the venous drainage through primary and secondary pathways by using phase-contrast magnetic resonance imaging (MRI). Methods: We examined 26 patients (37.3 ± 13.9 years) with recurring migraine headaches and 26 age-and gender-matched controls with no neurologic disease (37.3 ± 13.7 years) on a 3 Tesla MR scanner. A 2D time-of-flight MR-venography of the upper neck region was performed to visualize the venous vasculature. Cine-phase contrast scans with highvelocity encoding were employed to quantify arterial inflow and flow in the primary venous channels (right and left jugular veins), whereas scans with low-velocity encoding were employed to quantify flow in the secondary venous channels (epidural, vertebral, and deep cervical veins). Results: Patients with migraine showed (i) a higher prevalence of dense secondary extracranial venous networks (15 vs. 2, P = 0.00002) and (ii) a significantly larger percentage of venous outflow through secondary channels (10.5% vs. 5.5%; of total cerebral blood flow, P = 0.02). This mainly included drainage through epidural, vertebral, and deep cervical veins. Conclusion: Migraine patients showed a significantly larger percentage of venous outflow through secondary channels. The mechanism of this alteration remains to be elucidated. Potential mechanisms include repeated release of vasoactive substances or growth factors.
KW - Migraine
KW - Phase-contrast imaging
KW - Secondary venous channels
KW - Total cerebral blood flow
KW - Venous outflow
UR - http://www.scopus.com/inward/record.url?scp=79960015063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960015063&partnerID=8YFLogxK
U2 - 10.1097/RLI.0b013e318210ecf5
DO - 10.1097/RLI.0b013e318210ecf5
M3 - Article
C2 - 21317790
AN - SCOPUS:79960015063
VL - 46
SP - 434
EP - 440
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 7
ER -