Altered cell-mediated immunity in asymptomatic colombian natives with positive or indeterminate serology for HTLV-I

Carlos Bernai, Ernesto Bernal, Roberto Patarca, Ruben Dario Bonilla, Cesar Arango

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Although HTLV-I infection has been associated with immunosuppression in symptomatic patients, no controlled study has been done in asymptomatic carriers. We evaluated delayed-type hypersensitivity (DTH) to seven antigens by multitest cell-mediated immunity (CMI) in 40 Colombian Indians, 10 HTLV- I-seropositive asymptomatic patients, and 30 matched controls. Multitest CMI was placed in the forearm and was read 48 hours later by the same physician. A positive reaction was defined as ≤2 mm. Hypoergic response was defined as <2 of 7 positive reactions per case or control. We found that HTLV-I- seropositive people had fewer positive reactions than matched controls (50% versus 64%, respectively; p < .04) but no significant difference was found in these populations in the evaluation of hypoergic responses. This study suggests the presence in asymptomatic HTLV-I-positive Colombian Indians of a marginal alteration of cell-mediated immunity that cannot be classified as hypoergic.

Original languageEnglish (US)
Pages (from-to)121-123
Number of pages3
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume19
Issue number2
DOIs
StatePublished - Oct 1 1998

Keywords

  • Cell-mediated immunity
  • HTLV-I

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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