Alterations of the female reproductive system in recipients of islet grafts

Pablo Cure, Antonello Pileggi, Tatiana Froud, Paul M. Norris, David Baidal, Agustin Cornejo, Muhammad M. Hafiz, Gaston Ponte, Raffaella Poggioli, Jeannie Yu, Amanda Saab, Gennaro Selvaggi, Camillo Ricordi, Rodolfo Alejandro

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background. Transplantation of allogeneic tissues is becoming a wider practice for the replacement of organ function lost to congenital or acquired pathologies. Chronic immunosuppression remains a necessity to prevent organ rejection, despite increased risks of infection, organ toxicity, and malignancies. Abnormalities of female gonadal function in patients of reproductive age are recognized, however, pathological alterations of the reproductive system in patients treated with new generation immunosuppressive drugs are still poorly documented. Methods. We report herein our observations of abnormalities of the reproductive system in 13 female recipients of allogeneic islets for type 1 diabetes, under immunosuppression therapy based on daclizumab induction and tacrolimus/ sirolimus maintenance. Results. Menstrual cycle alterations and clinically significant ovarian cysts were frequently observed in our patients, some requiring medical or surgical intervention. All ovarian cysts appeared of benign nature. Conclusions. Our findings suggest that pre- and posttransplant evaluation of female patients should include menstrual history, baseline pelvic ultrasound, and hormonal levels to assess the presence and monitor the progression of such alterations.

Original languageEnglish
Pages (from-to)1576-1581
Number of pages6
JournalTransplantation
Volume78
Issue number11
DOIs
StatePublished - Dec 15 2004

Fingerprint

Transplants
Ovarian Cysts
Immunosuppression
Tissue Transplantation
Homologous Transplantation
Tacrolimus
Sirolimus
Immunosuppressive Agents
Menstrual Cycle
Type 1 Diabetes Mellitus
Maintenance
Pathology
Infection
Pharmaceutical Preparations
Neoplasms
Therapeutics
daclizumab

Keywords

  • Immunosuppression
  • Islet transplantation
  • Menstrual irregularities
  • Ovarian cysts

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Alterations of the female reproductive system in recipients of islet grafts. / Cure, Pablo; Pileggi, Antonello; Froud, Tatiana; Norris, Paul M.; Baidal, David; Cornejo, Agustin; Hafiz, Muhammad M.; Ponte, Gaston; Poggioli, Raffaella; Yu, Jeannie; Saab, Amanda; Selvaggi, Gennaro; Ricordi, Camillo; Alejandro, Rodolfo.

In: Transplantation, Vol. 78, No. 11, 15.12.2004, p. 1576-1581.

Research output: Contribution to journalArticle

Cure, P, Pileggi, A, Froud, T, Norris, PM, Baidal, D, Cornejo, A, Hafiz, MM, Ponte, G, Poggioli, R, Yu, J, Saab, A, Selvaggi, G, Ricordi, C & Alejandro, R 2004, 'Alterations of the female reproductive system in recipients of islet grafts', Transplantation, vol. 78, no. 11, pp. 1576-1581. https://doi.org/10.1097/01.TP.0000147301.41864.C0
Cure, Pablo ; Pileggi, Antonello ; Froud, Tatiana ; Norris, Paul M. ; Baidal, David ; Cornejo, Agustin ; Hafiz, Muhammad M. ; Ponte, Gaston ; Poggioli, Raffaella ; Yu, Jeannie ; Saab, Amanda ; Selvaggi, Gennaro ; Ricordi, Camillo ; Alejandro, Rodolfo. / Alterations of the female reproductive system in recipients of islet grafts. In: Transplantation. 2004 ; Vol. 78, No. 11. pp. 1576-1581.
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