Alterations of the female reproductive system in islet recipient receiving immunosuppression

Maria Isabel Del Olmo Garcia, Vincenzo Lauriola, Altagracia Gomez Aracena, Shari Messinger, Andrea Corrales, Camillo Ricordi, Rodolfo Alejandro

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Pancreatic islet allotransplantation is an option for patients with unstable type 1 diabetes mellitus (T1DM). Major improvements in islet isolation techniques and the implementation of steroid-free immunosuppressive regimens can maintain insulin independence in the majority of T1DM for at least 1 year after transplantation. Recent studies have emphasized the impact of sirolimus on female reproductive tract. In this communication we report on the alterations of the female reproductive tract in 18 chronically immunosuppressed patients with T1DM following allogenic islet transplantation. Previous research has shown development of ovarian cysts in islet transplant patients receiving sirolimus. We extensively reevaluated this and other possible side effects on the female reproductive system. These side effects have been underestimated, although they are significant, requiring surgical or intensive medical treatment. Pre- and posttransplant gynecological evalua- tion should be performed to address the development of complications secondary to sirolimus in order to intervene sooner with alternative therapies.

Original languageEnglish (US)
Pages (from-to)1649-1651
Number of pages3
JournalCell transplantation
Issue number10
StatePublished - 2011


  • Immunosuppression
  • Islet transplantation
  • Reproductive system
  • Sirolimus
  • Type 1 diabetes

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation
  • Biomedical Engineering


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