Alterations of the female reproductive system in islet recipient receiving immunosuppression

Maria Isabel Del Olmo Garcia, Vincenzo Lauriola, Altagracia Gomez Aracena, Shari Messinger, Andrea Corrales, Camillo Ricordi, Rodolfo Alejandro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pancreatic islet allotransplantation is an option for patients with unstable type 1 diabetes mellitus (T1DM). Major improvements in islet isolation techniques and the implementation of steroid-free immunosuppressive regimens can maintain insulin independence in the majority of T1DM for at least 1 year after transplantation. Recent studies have emphasized the impact of sirolimus on female reproductive tract. In this communication we report on the alterations of the female reproductive tract in 18 chronically immunosuppressed patients with T1DM following allogenic islet transplantation. Previous research has shown development of ovarian cysts in islet transplant patients receiving sirolimus. We extensively reevaluated this and other possible side effects on the female reproductive system. These side effects have been underestimated, although they are significant, requiring surgical or intensive medical treatment. Pre- and posttransplant gynecological evalua- tion should be performed to address the development of complications secondary to sirolimus in order to intervene sooner with alternative therapies.

Original languageEnglish
Pages (from-to)1649-1651
Number of pages3
JournalCell Transplantation
Volume20
Issue number10
StatePublished - Dec 1 2011

Fingerprint

Sirolimus
Medical problems
Type 1 Diabetes Mellitus
Immunosuppression
Islets of Langerhans Transplantation
Ovarian Cysts
Transplants
Insulin
Homologous Transplantation
Immunosuppressive Agents
Complementary Therapies
Islets of Langerhans
Transplantation
Steroids
Communication
Research
Therapeutics

Keywords

  • Immunosuppression
  • Islet transplantation
  • Reproductive system
  • Sirolimus
  • Type 1 diabetes

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation
  • Biomedical Engineering

Cite this

Alterations of the female reproductive system in islet recipient receiving immunosuppression. / Garcia, Maria Isabel Del Olmo; Lauriola, Vincenzo; Aracena, Altagracia Gomez; Messinger, Shari; Corrales, Andrea; Ricordi, Camillo; Alejandro, Rodolfo.

In: Cell Transplantation, Vol. 20, No. 10, 01.12.2011, p. 1649-1651.

Research output: Contribution to journalArticle

Garcia, Maria Isabel Del Olmo ; Lauriola, Vincenzo ; Aracena, Altagracia Gomez ; Messinger, Shari ; Corrales, Andrea ; Ricordi, Camillo ; Alejandro, Rodolfo. / Alterations of the female reproductive system in islet recipient receiving immunosuppression. In: Cell Transplantation. 2011 ; Vol. 20, No. 10. pp. 1649-1651.
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