Alterations of Axin protein expression during cardiac remodeling in rats

Ping Li, Jin Liang Li, Feng Yin, Jie Yan, Xin Heng Feng, Zhao Ping Li, Qi De Han, You Yi Zhang

Research output: Contribution to journalArticle

Abstract

The purpose of the present study was to observe the expression of Axin protein during cardiac remodeling in rats. Cardiac remodeling animal models were prepared with the methods of jugular venous norepinephrine (NE)-infusion or arterial-vein fistula (AVF). The ultrasonic parameters of rat hearts were recorded before sacrifice. The expressions of Axin protein were determined by Western blot in rat hearts from different remodeling models as well as cultured cardiac fibroblasts from adult rats. Cardiac concentric hypertrophy and fibrosis was induced by 3-day jugular vein infusion of NE in rats. The expression of Axin in the left ventricles increased significantly compared with that of the control group. Cardiac eccentric hypertrophy without fibrosis was induced by A-V fistula for one week in rats, and no change in Axin protein expression in the left ventricles was observed. In cultured adult rat cardiac fibroblasts, NE treatment for 24 h increased significantly the Axin protein level. It is therefore concluded that Axin protein was expressed in rat heart and increased significantly in left ventricles during NE-induced rat cardiac remodeling, which may be relevant to cardiac fibrosis.

Original languageEnglish
Pages (from-to)331-335
Number of pages5
JournalActa Physiologica Sinica
Volume55
Issue number3
StatePublished - Jun 25 2003
Externally publishedYes

Fingerprint

Axin Protein
Norepinephrine
Heart Ventricles
Fibrosis
Cardiomegaly
Fistula
Fibroblasts
Jugular Veins
Ultrasonics
Veins

Keywords

  • Fibrosis
  • Norepinephrine
  • Pathology
  • Ventricular remodeling

ASJC Scopus subject areas

  • Physiology

Cite this

Li, P., Li, J. L., Yin, F., Yan, J., Feng, X. H., Li, Z. P., ... Zhang, Y. Y. (2003). Alterations of Axin protein expression during cardiac remodeling in rats. Acta Physiologica Sinica, 55(3), 331-335.

Alterations of Axin protein expression during cardiac remodeling in rats. / Li, Ping; Li, Jin Liang; Yin, Feng; Yan, Jie; Feng, Xin Heng; Li, Zhao Ping; Han, Qi De; Zhang, You Yi.

In: Acta Physiologica Sinica, Vol. 55, No. 3, 25.06.2003, p. 331-335.

Research output: Contribution to journalArticle

Li, P, Li, JL, Yin, F, Yan, J, Feng, XH, Li, ZP, Han, QD & Zhang, YY 2003, 'Alterations of Axin protein expression during cardiac remodeling in rats', Acta Physiologica Sinica, vol. 55, no. 3, pp. 331-335.
Li P, Li JL, Yin F, Yan J, Feng XH, Li ZP et al. Alterations of Axin protein expression during cardiac remodeling in rats. Acta Physiologica Sinica. 2003 Jun 25;55(3):331-335.
Li, Ping ; Li, Jin Liang ; Yin, Feng ; Yan, Jie ; Feng, Xin Heng ; Li, Zhao Ping ; Han, Qi De ; Zhang, You Yi. / Alterations of Axin protein expression during cardiac remodeling in rats. In: Acta Physiologica Sinica. 2003 ; Vol. 55, No. 3. pp. 331-335.
@article{2f1b7b2228a942a2a29e44057acec968,
title = "Alterations of Axin protein expression during cardiac remodeling in rats",
abstract = "The purpose of the present study was to observe the expression of Axin protein during cardiac remodeling in rats. Cardiac remodeling animal models were prepared with the methods of jugular venous norepinephrine (NE)-infusion or arterial-vein fistula (AVF). The ultrasonic parameters of rat hearts were recorded before sacrifice. The expressions of Axin protein were determined by Western blot in rat hearts from different remodeling models as well as cultured cardiac fibroblasts from adult rats. Cardiac concentric hypertrophy and fibrosis was induced by 3-day jugular vein infusion of NE in rats. The expression of Axin in the left ventricles increased significantly compared with that of the control group. Cardiac eccentric hypertrophy without fibrosis was induced by A-V fistula for one week in rats, and no change in Axin protein expression in the left ventricles was observed. In cultured adult rat cardiac fibroblasts, NE treatment for 24 h increased significantly the Axin protein level. It is therefore concluded that Axin protein was expressed in rat heart and increased significantly in left ventricles during NE-induced rat cardiac remodeling, which may be relevant to cardiac fibrosis.",
keywords = "Fibrosis, Norepinephrine, Pathology, Ventricular remodeling",
author = "Ping Li and Li, {Jin Liang} and Feng Yin and Jie Yan and Feng, {Xin Heng} and Li, {Zhao Ping} and Han, {Qi De} and Zhang, {You Yi}",
year = "2003",
month = "6",
day = "25",
language = "English",
volume = "55",
pages = "331--335",
journal = "Sheng li xue bao [Acta physiologica Sinica]",
issn = "0371-0874",
publisher = "Kexue Chubaneshe/Science Press",
number = "3",

}

TY - JOUR

T1 - Alterations of Axin protein expression during cardiac remodeling in rats

AU - Li, Ping

AU - Li, Jin Liang

AU - Yin, Feng

AU - Yan, Jie

AU - Feng, Xin Heng

AU - Li, Zhao Ping

AU - Han, Qi De

AU - Zhang, You Yi

PY - 2003/6/25

Y1 - 2003/6/25

N2 - The purpose of the present study was to observe the expression of Axin protein during cardiac remodeling in rats. Cardiac remodeling animal models were prepared with the methods of jugular venous norepinephrine (NE)-infusion or arterial-vein fistula (AVF). The ultrasonic parameters of rat hearts were recorded before sacrifice. The expressions of Axin protein were determined by Western blot in rat hearts from different remodeling models as well as cultured cardiac fibroblasts from adult rats. Cardiac concentric hypertrophy and fibrosis was induced by 3-day jugular vein infusion of NE in rats. The expression of Axin in the left ventricles increased significantly compared with that of the control group. Cardiac eccentric hypertrophy without fibrosis was induced by A-V fistula for one week in rats, and no change in Axin protein expression in the left ventricles was observed. In cultured adult rat cardiac fibroblasts, NE treatment for 24 h increased significantly the Axin protein level. It is therefore concluded that Axin protein was expressed in rat heart and increased significantly in left ventricles during NE-induced rat cardiac remodeling, which may be relevant to cardiac fibrosis.

AB - The purpose of the present study was to observe the expression of Axin protein during cardiac remodeling in rats. Cardiac remodeling animal models were prepared with the methods of jugular venous norepinephrine (NE)-infusion or arterial-vein fistula (AVF). The ultrasonic parameters of rat hearts were recorded before sacrifice. The expressions of Axin protein were determined by Western blot in rat hearts from different remodeling models as well as cultured cardiac fibroblasts from adult rats. Cardiac concentric hypertrophy and fibrosis was induced by 3-day jugular vein infusion of NE in rats. The expression of Axin in the left ventricles increased significantly compared with that of the control group. Cardiac eccentric hypertrophy without fibrosis was induced by A-V fistula for one week in rats, and no change in Axin protein expression in the left ventricles was observed. In cultured adult rat cardiac fibroblasts, NE treatment for 24 h increased significantly the Axin protein level. It is therefore concluded that Axin protein was expressed in rat heart and increased significantly in left ventricles during NE-induced rat cardiac remodeling, which may be relevant to cardiac fibrosis.

KW - Fibrosis

KW - Norepinephrine

KW - Pathology

KW - Ventricular remodeling

UR - http://www.scopus.com/inward/record.url?scp=0042155343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042155343&partnerID=8YFLogxK

M3 - Article

C2 - 12817302

AN - SCOPUS:0042155343

VL - 55

SP - 331

EP - 335

JO - Sheng li xue bao [Acta physiologica Sinica]

JF - Sheng li xue bao [Acta physiologica Sinica]

SN - 0371-0874

IS - 3

ER -