Alterations of Axin protein expression during cardiac remodeling in rats

Ping Li, Jin Liang Li, Feng Yin, Jie Yan, Xin Heng Feng, Zhao Ping Li, Qi De Han, You Yi Zhang

Research output: Contribution to journalArticle

Abstract

The purpose of the present study was to observe the expression of Axin protein during cardiac remodeling in rats. Cardiac remodeling animal models were prepared with the methods of jugular venous norepinephrine (NE)-infusion or arterial-vein fistula (AVF). The ultrasonic parameters of rat hearts were recorded before sacrifice. The expressions of Axin protein were determined by Western blot in rat hearts from different remodeling models as well as cultured cardiac fibroblasts from adult rats. Cardiac concentric hypertrophy and fibrosis was induced by 3-day jugular vein infusion of NE in rats. The expression of Axin in the left ventricles increased significantly compared with that of the control group. Cardiac eccentric hypertrophy without fibrosis was induced by A-V fistula for one week in rats, and no change in Axin protein expression in the left ventricles was observed. In cultured adult rat cardiac fibroblasts, NE treatment for 24 h increased significantly the Axin protein level. It is therefore concluded that Axin protein was expressed in rat heart and increased significantly in left ventricles during NE-induced rat cardiac remodeling, which may be relevant to cardiac fibrosis.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalActa Physiologica Sinica
Volume55
Issue number3
StatePublished - Jun 25 2003

Keywords

  • Fibrosis
  • Norepinephrine
  • Pathology
  • Ventricular remodeling

ASJC Scopus subject areas

  • Physiology

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  • Cite this

    Li, P., Li, J. L., Yin, F., Yan, J., Feng, X. H., Li, Z. P., Han, Q. D., & Zhang, Y. Y. (2003). Alterations of Axin protein expression during cardiac remodeling in rats. Acta Physiologica Sinica, 55(3), 331-335.