Alterations in Thrombosis and Fibrinolysis in the Metabolic Syndrome

Juan Viles Gonzalez, Brian G. Choi, Juan J. Badimón

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The intricate relationship between obesity, diabetes, Metabolic Syndrome, and the consequent development of atherosclerosis has now gained the attention of a substantial part of the scientific community, given their epidemiologic implications. It is accepted that obesity predisposes for the development of diabetes and that these two entities in the same individual will lead to the Metabolic Syndrome. All the clinical characteristic associated with the Metabolic Syndrome have been recognized as major contributors for the development of atherosclerosis and its acute complications. Different definitions of the Metabolic Syndrome exist: one from the 2001 National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III), and the other from The World Health Organization (WHO). Regardless of the definition, the net effect of dyslipidemia, hypertension and hyperglycemia results in endothelial cell dysfunction. The consequence of endothelial dysfunction is downregulation of fibrinolysis and upregulation of thrombosis and platelet aggregation. By this mechanism, Metabolic Syndrome unchecked leads to acceleration of atherosclerosis and its subsequent acute complications. Herein, we explore how Metabolic Syndrome, by creating endothelial dysfunction, mechanistically results in alterations in thrombosis and fibrinolysis.

Original languageEnglish (US)
Title of host publicationThe Metabolic Syndrome at the Beginning of the XXI Century: A Genetic and Molecular Approach
PublisherElsevier Inc.
Pages359-368
Number of pages10
ISBN (Print)8481748927, 9788481748925
DOIs
StatePublished - Nov 11 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Viles Gonzalez, J., Choi, B. G., & Badimón, J. J. (2005). Alterations in Thrombosis and Fibrinolysis in the Metabolic Syndrome. In The Metabolic Syndrome at the Beginning of the XXI Century: A Genetic and Molecular Approach (pp. 359-368). Elsevier Inc.. https://doi.org/10.1016/B978-84-8174-892-5.50022-X