Alterations in regional brain concentrations of neurotensin and bombesin in Parkinson's disease

G. Bissette, Charles Nemeroff, M. W. Decker, J. S. Kizer, Y. Agid, F. Javoy-Agid

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Frozen samples of postmortem human brain tissue from patients with Parkinson's disease (n = 25) and control patients who died without neurological disease (n = 25) were assayed for neurotensin and bombesin by specific radioimmunoassay. Twelve brain regions were examined: substantia nigra, ventral tegmental area, periaqueductal gray matter, caudate nucleus, putamen, globus pallidus, amygdala, hippocampus, nucleus accumbens, frontal cortex, cingulate cortex, and entorhinal cortex. In patients with Parkinson's disease, the concentration of bombesin was significantly decreased in the caudate nucleus and globus pallidus, and the concentration of neurotensin was significantly reduced in the hippocampus. The concentration of neither peptide was significantly altered in the substantia nigra or ventral tegmental area, two regions known to exhibit reductions in other neurotransmitter substances.

Original languageEnglish
Pages (from-to)324-328
Number of pages5
JournalAnnals of Neurology
Volume17
Issue number4
DOIs
StatePublished - Jul 24 1985
Externally publishedYes

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Bombesin
Neurotensin
Parkinson Disease
Ventral Tegmental Area
Globus Pallidus
Caudate Nucleus
Substantia Nigra
Hippocampus
Brain
Periaqueductal Gray
Entorhinal Cortex
Putamen
Gyrus Cinguli
Nucleus Accumbens
Frontal Lobe
Amygdala
Radioimmunoassay
Neurotransmitter Agents
Peptides

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alterations in regional brain concentrations of neurotensin and bombesin in Parkinson's disease. / Bissette, G.; Nemeroff, Charles; Decker, M. W.; Kizer, J. S.; Agid, Y.; Javoy-Agid, F.

In: Annals of Neurology, Vol. 17, No. 4, 24.07.1985, p. 324-328.

Research output: Contribution to journalArticle

Bissette, G. ; Nemeroff, Charles ; Decker, M. W. ; Kizer, J. S. ; Agid, Y. ; Javoy-Agid, F. / Alterations in regional brain concentrations of neurotensin and bombesin in Parkinson's disease. In: Annals of Neurology. 1985 ; Vol. 17, No. 4. pp. 324-328.
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