Alterations in rat spinal cord cGMP by peripheral nerve injury and adrenal medullary transplantation

Julie B. Siegan, Aldric T. Hama, Jacqueline Sagen

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Adrenal medullary chromaffin cells implanted into the spinal subarachnoid space can reduce abnormal pain-related responses in chronic pain models. Persistent pain is thought to involve the activation of N-methyl-D-aspartate (NMDA) receptors and subsequent production of nitric oxide (NO) and cyclic guanosine 3',5'-monophosphate (cGMP). Changes in dorsal horn levels of cGMP in the rat were determined in conjunction with alterations in pain behaviors following peripheral nerve injury and adrenal medullary transplantation. Results indicated increased spinal cGMP levels in parallel with thermal and mechanical hyperalgesia and tactile allodynia consequent to chronic constriction injury of the sciatic nerve in rats. Adrenal medullary, but not control transplants, attenuated the hyperalgesia and allodynia and decreased spinal cGMP content. These results suggest that adrenal medullary transplants may reduce abnormal pain by intervention in the spinal NMDA-NO cascade.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalNeuroscience Letters
Issue number1
StatePublished - Aug 30 1996
Externally publishedYes


  • Adrenal medulla
  • Analgesia
  • Chromaffin cells
  • Dorsal horn
  • Hyperalgesia
  • N-Methyl-D-aspartate
  • Neural transplants
  • Nitric oxide

ASJC Scopus subject areas

  • Neuroscience(all)


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