Alterations in platelet serotonin transporter binding in women with postpartum onset major depression

Donald J Newport, Michael J. Owens, David L. Knight, Kim Ragan, Neal Morgan, Charles Nemeroff, Zachary N. Stowe

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

There is considerable debate as to whether postpartum depression (PPD) is biologically distinct from other depressive syndromes. Although abnormalities in serotonergic neural systems have repeatedly been reported in depression, few such studies have been conducted in PPD. In the present study, platelet serotonin transporter (SERT) binding was assessed using [3H] paroxetine in 14 depressed pregnant women, 31 normal healthy pregnant women, 39 depressed postpartum women, and 27 normal healthy postpartum women; all of the subjects were drug-free. Significant differences were detected among the 4 groups with respect to the dissociation constant (Kd) of platelet binding sites for [3H]paroxetine with the highest Kd values among those with PPD. The density (Bmax) of platelet binding sites for [3H]paroxetine did not differ between the study groups. These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium.

Original languageEnglish
Pages (from-to)467-473
Number of pages7
JournalJournal of Psychiatric Research
Volume38
Issue number5
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

Fingerprint

Postpartum Depression
Serotonin Plasma Membrane Transport Proteins
Paroxetine
Postpartum Period
Depression
Pregnant Women
Blood Platelets
Binding Sites
Dissociative Disorders
Depressive Disorder
Pharmaceutical Preparations

Keywords

  • Major depression
  • Platelet
  • Postpartum
  • Pregnancy
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Alterations in platelet serotonin transporter binding in women with postpartum onset major depression. / Newport, Donald J; Owens, Michael J.; Knight, David L.; Ragan, Kim; Morgan, Neal; Nemeroff, Charles; Stowe, Zachary N.

In: Journal of Psychiatric Research, Vol. 38, No. 5, 01.09.2004, p. 467-473.

Research output: Contribution to journalArticle

Newport, Donald J ; Owens, Michael J. ; Knight, David L. ; Ragan, Kim ; Morgan, Neal ; Nemeroff, Charles ; Stowe, Zachary N. / Alterations in platelet serotonin transporter binding in women with postpartum onset major depression. In: Journal of Psychiatric Research. 2004 ; Vol. 38, No. 5. pp. 467-473.
@article{cb36b894330c4cb7aace46aacd071bd4,
title = "Alterations in platelet serotonin transporter binding in women with postpartum onset major depression",
abstract = "There is considerable debate as to whether postpartum depression (PPD) is biologically distinct from other depressive syndromes. Although abnormalities in serotonergic neural systems have repeatedly been reported in depression, few such studies have been conducted in PPD. In the present study, platelet serotonin transporter (SERT) binding was assessed using [3H] paroxetine in 14 depressed pregnant women, 31 normal healthy pregnant women, 39 depressed postpartum women, and 27 normal healthy postpartum women; all of the subjects were drug-free. Significant differences were detected among the 4 groups with respect to the dissociation constant (Kd) of platelet binding sites for [3H]paroxetine with the highest Kd values among those with PPD. The density (Bmax) of platelet binding sites for [3H]paroxetine did not differ between the study groups. These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium.",
keywords = "Major depression, Platelet, Postpartum, Pregnancy, Serotonin",
author = "Newport, {Donald J} and Owens, {Michael J.} and Knight, {David L.} and Kim Ragan and Neal Morgan and Charles Nemeroff and Stowe, {Zachary N.}",
year = "2004",
month = "9",
day = "1",
doi = "10.1016/j.jpsychires.2004.01.011",
language = "English",
volume = "38",
pages = "467--473",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Alterations in platelet serotonin transporter binding in women with postpartum onset major depression

AU - Newport, Donald J

AU - Owens, Michael J.

AU - Knight, David L.

AU - Ragan, Kim

AU - Morgan, Neal

AU - Nemeroff, Charles

AU - Stowe, Zachary N.

PY - 2004/9/1

Y1 - 2004/9/1

N2 - There is considerable debate as to whether postpartum depression (PPD) is biologically distinct from other depressive syndromes. Although abnormalities in serotonergic neural systems have repeatedly been reported in depression, few such studies have been conducted in PPD. In the present study, platelet serotonin transporter (SERT) binding was assessed using [3H] paroxetine in 14 depressed pregnant women, 31 normal healthy pregnant women, 39 depressed postpartum women, and 27 normal healthy postpartum women; all of the subjects were drug-free. Significant differences were detected among the 4 groups with respect to the dissociation constant (Kd) of platelet binding sites for [3H]paroxetine with the highest Kd values among those with PPD. The density (Bmax) of platelet binding sites for [3H]paroxetine did not differ between the study groups. These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium.

AB - There is considerable debate as to whether postpartum depression (PPD) is biologically distinct from other depressive syndromes. Although abnormalities in serotonergic neural systems have repeatedly been reported in depression, few such studies have been conducted in PPD. In the present study, platelet serotonin transporter (SERT) binding was assessed using [3H] paroxetine in 14 depressed pregnant women, 31 normal healthy pregnant women, 39 depressed postpartum women, and 27 normal healthy postpartum women; all of the subjects were drug-free. Significant differences were detected among the 4 groups with respect to the dissociation constant (Kd) of platelet binding sites for [3H]paroxetine with the highest Kd values among those with PPD. The density (Bmax) of platelet binding sites for [3H]paroxetine did not differ between the study groups. These data suggest that PPD may be associated with unique alterations in serotonergic function that are specific to the puerperium.

KW - Major depression

KW - Platelet

KW - Postpartum

KW - Pregnancy

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=4544269730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544269730&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychires.2004.01.011

DO - 10.1016/j.jpsychires.2004.01.011

M3 - Article

VL - 38

SP - 467

EP - 473

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 5

ER -