TY - JOUR
T1 - Alterations in nociception and body temperature after intracisternal administration of neurotensin, β-endorphin, other endogenous peptides, and morphine
AU - Nemeroff, C. B.
AU - Osbahr, A. J.
AU - Manberg, P. J.
AU - Ervin, G. N.
AU - Prange, A. J.
PY - 1979/12/1
Y1 - 1979/12/1
N2 - The antinociceptive and hypothermic effects of intracisternal administration of 11 endogenous neuropeptides and morphine were evaluated in mice. Of the substances tested, only neurotensin (NT) and β-endorphin exerted significant antinociceptive and hypothermic effects; NT was the most potent antinociceptive agent via this route of administration. . Both NT and β-endorphin were, on a molar basis, considerably more potent antinociceptive agents than morphine, [Met]enkephalin, or [Leu]enkephalin. NT-induced analgesia and hypothermia both were significantly dose-dependent. Substance P was found to produce significant hyperalgesia and hyperthermia. Bombesin produced a significant hypothermic effect, whereas somatostatin and luteinizing hormone-releasing hormone (luliberin) produced hyperthermia. None of the other peptides studied [bradykinin, thyrotropin-releasing factor (thyroliberin), melanocyte-stimulating hormone release-inhibiting factor (melanostatin), somatostatin, [Met]enkephalin, and [Leu]enkephalin] produced any significant alterations in colonic temperature or response to a noxious stimulus with the doses tested. These data demonstrate that NT and β-endorphin, two endogenous brain peptides, are potent in inducing hypothermia and in producing an antinociceptive state.
AB - The antinociceptive and hypothermic effects of intracisternal administration of 11 endogenous neuropeptides and morphine were evaluated in mice. Of the substances tested, only neurotensin (NT) and β-endorphin exerted significant antinociceptive and hypothermic effects; NT was the most potent antinociceptive agent via this route of administration. . Both NT and β-endorphin were, on a molar basis, considerably more potent antinociceptive agents than morphine, [Met]enkephalin, or [Leu]enkephalin. NT-induced analgesia and hypothermia both were significantly dose-dependent. Substance P was found to produce significant hyperalgesia and hyperthermia. Bombesin produced a significant hypothermic effect, whereas somatostatin and luteinizing hormone-releasing hormone (luliberin) produced hyperthermia. None of the other peptides studied [bradykinin, thyrotropin-releasing factor (thyroliberin), melanocyte-stimulating hormone release-inhibiting factor (melanostatin), somatostatin, [Met]enkephalin, and [Leu]enkephalin] produced any significant alterations in colonic temperature or response to a noxious stimulus with the doses tested. These data demonstrate that NT and β-endorphin, two endogenous brain peptides, are potent in inducing hypothermia and in producing an antinociceptive state.
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U2 - 10.1073/pnas.76.10.5368
DO - 10.1073/pnas.76.10.5368
M3 - Article
C2 - 291952
AN - SCOPUS:0018668629
VL - 76
SP - 5368
EP - 5371
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 10
ER -