Alterations in components of the pineal melatonin synthetic pathway by acute insulin stress in the rat and Syrian hamster

Thomas Champney, Richard W. Steger, Douglas S. Christie, Russel J. Reiter

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Acute insulin stress increased plasma catecholamine levels in both the Syrian hamster and albino rat within 3 h after an intraperitoneal injection of either 5 or 10 units of insulin. In the rat, this stress caused a concurrent increase in pineal serotonin N-acetyltransferase (NAT) activity and melatonin content with no observable change in hydroxyindole-O-methyltransferase (HIOMT) activity. In the hamster, on the other hand, acute insulin stress did not alter pineal NAT activity, but depressed both HIOMT activity and melatonin content up to 3 h after the stress. These results present further evidence that catecholamines do not control hamster pineal melatonin synthesis by the same mechanism as observed in the rat.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalBrain Research
Volume338
Issue number1
DOIs
StatePublished - Jul 8 1985
Externally publishedYes

Fingerprint

Mesocricetus
Acetylserotonin O-Methyltransferase
Melatonin
Insulin
Cricetinae
Catecholamines
Arylalkylamine N-Acetyltransferase
Acetyltransferases
Intraperitoneal Injections

Keywords

  • albino rat
  • catecholamines
  • melatonin
  • pineal
  • stress
  • Syrian hamster

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Alterations in components of the pineal melatonin synthetic pathway by acute insulin stress in the rat and Syrian hamster. / Champney, Thomas; Steger, Richard W.; Christie, Douglas S.; Reiter, Russel J.

In: Brain Research, Vol. 338, No. 1, 08.07.1985, p. 25-32.

Research output: Contribution to journalArticle

Champney, Thomas ; Steger, Richard W. ; Christie, Douglas S. ; Reiter, Russel J. / Alterations in components of the pineal melatonin synthetic pathway by acute insulin stress in the rat and Syrian hamster. In: Brain Research. 1985 ; Vol. 338, No. 1. pp. 25-32.
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