Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders

G. Bissette, E. Widerlov, H. Walleus, I. Karlsson, K. Eklund, A. Forsman, Charles Nemeroff

Research output: Contribution to journalArticle

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Abstract

The concentration of somatostatinlike immunoreactivity in cerebrospinal fluid (CSF) from normal, healthy volunteers (n = 10) and patients with DSM-III diagnoses of major depression (n = 17), schizophrenia (n = 11), or dementia (n = 29) was measured by a sensitive and specific radioimmunoassay. Statistically significant decreases in CSF concentrations of somatostatinlike immunoreactivity were seen in all three patient populations when compared with controls. These findings confirm previous reports of decreased concentrations of somatostatinlike immunoreactivity in the CSF of patients with depression and dementia and extend this observation to patients with schizophrenia as well. These findings are concordant with the view that reductions in somatostatinlike immunoreactivity concentrations are associated with diseases in which cognitive function is disturbed.

Original languageEnglish
Pages (from-to)1148-1151
Number of pages4
JournalArchives of General Psychiatry
Volume43
Issue number12
StatePublished - Dec 1 1986
Externally publishedYes

Fingerprint

Cerebrospinal Fluid
Dementia
Schizophrenia
Healthy Volunteers
Depression
Diagnostic and Statistical Manual of Mental Disorders
Cognition
Radioimmunoassay
somatostatin-like peptides
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Bissette, G., Widerlov, E., Walleus, H., Karlsson, I., Eklund, K., Forsman, A., & Nemeroff, C. (1986). Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders. Archives of General Psychiatry, 43(12), 1148-1151.

Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders. / Bissette, G.; Widerlov, E.; Walleus, H.; Karlsson, I.; Eklund, K.; Forsman, A.; Nemeroff, Charles.

In: Archives of General Psychiatry, Vol. 43, No. 12, 01.12.1986, p. 1148-1151.

Research output: Contribution to journalArticle

Bissette, G, Widerlov, E, Walleus, H, Karlsson, I, Eklund, K, Forsman, A & Nemeroff, C 1986, 'Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders', Archives of General Psychiatry, vol. 43, no. 12, pp. 1148-1151.
Bissette G, Widerlov E, Walleus H, Karlsson I, Eklund K, Forsman A et al. Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders. Archives of General Psychiatry. 1986 Dec 1;43(12):1148-1151.
Bissette, G. ; Widerlov, E. ; Walleus, H. ; Karlsson, I. ; Eklund, K. ; Forsman, A. ; Nemeroff, Charles. / Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders. In: Archives of General Psychiatry. 1986 ; Vol. 43, No. 12. pp. 1148-1151.
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