Alterations in Cerebrospinal Fluid Concentrations of Somatostatinlike Immunoreactivity in Neuropsychiatric Disorders

Garth Bissette, Erik Widerlöv, Helena Walléus, Ingvar Karlsson, Kurt Eklund, Anders Forsman, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

The concentration of somatostatinlike immunoreactivity in cerebrospinal fluid (CSF) from normal, healthy volunteers (n = 10) and patients with DSM-III diagnoses of major depression (n = 17), schizophrenia (n = 11), or dementia (n = 29) was measured by a sensitive and specific radioimmunoassay. Statistically significant decreases in CSF concentrations of somatostatinlike immunoreactivity were seen in all three patient populations when compared with controls. These findings confirm previous reports of decreased concentrations of somatostatinlike immunoreactivity in the CSF of patients with depression and dementia and extend this observation to patients with schizophrenia as well. These findings are concordant with the view that reductions in somatostatinlike immunoreactivity concentrations are associated with diseases in which cognitive function is disturbed.

Original languageEnglish (US)
Pages (from-to)1148-1151
Number of pages4
JournalArchives of General Psychiatry
Volume43
Issue number12
DOIs
StatePublished - Dec 1986
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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