Alterations in cerebrospinal fluid concentrations of somatostatin-like immunoreactivity in chronic pain patients

Bruno J. Urban, Randal D. France, Garth Bissette, Fred J. Spielman, Charles Nemeroff

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Concentrations of somatostatin-like immunoreactivity in cerebrospinal fluid were significantly reduced in chronic pain patients compared to control patients without chronic pain. This difference was not influenced by demographic or clinical characteristics. Somatostatin has been shown to be a neurotransmitter in animal nociception; pharmacologic doses of this substance have moderated human pain. Our findings provide evidence that somatostatin may be involved in the pathogenesis of the chronic pain state.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalPain
Volume33
Issue number2
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Chronic Pain
Cerebrospinal Fluid
Somatostatin
Nociception
Neurotransmitter Agents
Demography
Pain
somatostatin-like peptides

Keywords

  • Chronic low back pain
  • CSF-somatostatin
  • Depression

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

Cite this

Alterations in cerebrospinal fluid concentrations of somatostatin-like immunoreactivity in chronic pain patients. / Urban, Bruno J.; France, Randal D.; Bissette, Garth; Spielman, Fred J.; Nemeroff, Charles.

In: Pain, Vol. 33, No. 2, 01.01.1988, p. 169-172.

Research output: Contribution to journalArticle

Urban, Bruno J. ; France, Randal D. ; Bissette, Garth ; Spielman, Fred J. ; Nemeroff, Charles. / Alterations in cerebrospinal fluid concentrations of somatostatin-like immunoreactivity in chronic pain patients. In: Pain. 1988 ; Vol. 33, No. 2. pp. 169-172.
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