Alterations in cerebrospinal fluid concentrations of somatostatin-like immunoreactivity in chronic pain patients

Bruno J. Urban, Randal D. France, Garth Bissette, Fred J. Spielman, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Concentrations of somatostatin-like immunoreactivity in cerebrospinal fluid were significantly reduced in chronic pain patients compared to control patients without chronic pain. This difference was not influenced by demographic or clinical characteristics. Somatostatin has been shown to be a neurotransmitter in animal nociception; pharmacologic doses of this substance have moderated human pain. Our findings provide evidence that somatostatin may be involved in the pathogenesis of the chronic pain state.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalPain
Volume33
Issue number2
DOIs
StatePublished - May 1988
Externally publishedYes

Keywords

  • Chronic low back pain
  • CSF-somatostatin
  • Depression

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

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