Alterations in cerebral oxidative metabolism following traumatic brain injury

Michael De Fazio, Richard Rammo, Kristine H O'Phelan, Ross Bullock

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Traumatic brain injury (TBI) generates regional alterations in cerebral metabolism, leading to the potential evolution of persistent metabolic dysfunction. In the case of penetrating, firearm-related TBI, the pathophysiological mechanisms underlying these acute-phase metabolic derangements are not entirely understood-hindering the potential effectiveness of therapeutic intervention. The use of cerebral microdialysis to monitor biochemical alterations that occur, post-TBI, provides critical insight into the events that perpetuate neurological deterioration. Methods: Cerebral microdialysis was used to monitor alterations in the brain tissue chemistry of a 22-year-old female patient who sustained a penetrating gunshot wound to the head. Extracellular glucose, lactate, pyruvate, and lactate pyruvate ratio (LPR) were monitored over the course of the first-week post-injury. Results: Analysis of the microdialysate revealed sustained elevations in LPR with peaks in excess of those seen in patients who have sustained permanent ischemic injury. This interval of persistently elevated LPR was followed by a spontaneous reduction of values, to levels below the defined threshold for metabolic crisis, over a period of several days. Conclusions: Microdialysis studies may significantly improve the understanding of the metabolic alterations that occur in patients who sustain a variety of forms of neurotrauma. Ultimately, monitoring these variations in brain tissue chemistry will improve the insight into the neuropathological mechanisms underlying penetrating traumatic brain injury, and enhance the therapeutic approach of these patients.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalNeurocritical Care
Volume14
Issue number1
DOIs
StatePublished - Feb 1 2011

Fingerprint

Pyruvic Acid
Lactic Acid
Microdialysis
Brain Chemistry
Penetrating Head Injuries
Penetrating Wounds
Gunshot Wounds
Wounds and Injuries
Firearms
Head
Glucose
Traumatic Brain Injury
Therapeutics

Keywords

  • Cerebral oxidative metabolism
  • Lactate pyruvate ratio
  • Microdialysis
  • Penetrating traumatic brain injury
  • Trauma

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

Cite this

Alterations in cerebral oxidative metabolism following traumatic brain injury. / De Fazio, Michael; Rammo, Richard; O'Phelan, Kristine H; Bullock, Ross.

In: Neurocritical Care, Vol. 14, No. 1, 01.02.2011, p. 91-96.

Research output: Contribution to journalArticle

De Fazio, Michael ; Rammo, Richard ; O'Phelan, Kristine H ; Bullock, Ross. / Alterations in cerebral oxidative metabolism following traumatic brain injury. In: Neurocritical Care. 2011 ; Vol. 14, No. 1. pp. 91-96.
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