Alzheimer's disease (AD)-associated protein is present in train and cerebrospinal fluid of patients with AD but not in adult, nondemented, normal controls. This protein may respresent an abnormal epitope of the "tau" microtubule -associated protein and has been detected before the apparance of senile plaques and neurofibrillary tangles. The ount of AD-associated protein in the frontal and tempoed cortices in 93 cases of neuropathologically confirmed AD was compared with the amount that was present in 20 cases without AD. The amount of AD-associated protein was significantly increased in the cases of AD for both brain regions compared with that in the cases without AD. The presence of high levels of this protein is a useful adjunct, postmortem marker of the presence of AD and may eventrally lead to tests that allow early detection of individuals at risk for this disease.
|Original language||English (US)|
|Number of pages||4|
|Journal||Archives of General Psychiatry|
|State||Published - Nov 1991|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Psychiatry and Mental health