Alterations in Alzheimer's Disease—Associated Protein in Alzheimer's Disease Frontal and Temporal Cortex

Garth Bissette, Wayne H. Smith, Kenneth C. Dole, Barbara Crain, Hossein Ghanbari, Barney Miller, Charles B. Nemeroff

Research output: Contribution to journalArticle

7 Scopus citations


Alzheimer's disease (AD)-associated protein is present in train and cerebrospinal fluid of patients with AD but not in adult, nondemented, normal controls. This protein may respresent an abnormal epitope of the "tau" microtubule -associated protein and has been detected before the apparance of senile plaques and neurofibrillary tangles. The ount of AD-associated protein in the frontal and tempoed cortices in 93 cases of neuropathologically confirmed AD was compared with the amount that was present in 20 cases without AD. The amount of AD-associated protein was significantly increased in the cases of AD for both brain regions compared with that in the cases without AD. The presence of high levels of this protein is a useful adjunct, postmortem marker of the presence of AD and may eventrally lead to tests that allow early detection of individuals at risk for this disease.

Original languageEnglish (US)
Pages (from-to)1009-1012
Number of pages4
JournalArchives of General Psychiatry
Issue number11
StatePublished - Nov 1991
Externally publishedYes


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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