Alterations in Alzheimer's disease-associated protein in Alzheimer's disease frontal and temporal cortex

Garth Bissette, Wayne H. Smith, Kenneth C. Dole, Barbara Crain, Hossein Ghanbari, Barney Miller, Charles Nemeroff

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Alzheimer's disease (AD)-associated protein is present in train and cerebrospinal fluid of patients with AD but not in adult, nondemented, normal controls. This protein may respresent an abnormal epitope of the "tau" microtubule -associated protein and has been detected before the apparance of senile plaques and neurofibrillary tangles. The ount of AD-associated protein in the frontal and tempoed cortices in 93 cases of neuropathologically confirmed AD was compared with the amount that was present in 20 cases without AD. The amount of AD-associated protein was significantly increased in the cases of AD for both brain regions compared with that in the cases without AD. The presence of high levels of this protein is a useful adjunct, postmortem marker of the presence of AD and may eventrally lead to tests that allow early detection of individuals at risk for this disease.

Original languageEnglish
Pages (from-to)1009-1012
Number of pages4
JournalArchives of General Psychiatry
Volume48
Issue number11
StatePublished - Dec 1 1991
Externally publishedYes

Fingerprint

Frontal Lobe
Temporal Lobe
Alzheimer Disease
Proteins
Neurofibrillary Tangles
Microtubule-Associated Proteins
Amyloid Plaques
Cerebrospinal Fluid
Epitopes
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Bissette, G., Smith, W. H., Dole, K. C., Crain, B., Ghanbari, H., Miller, B., & Nemeroff, C. (1991). Alterations in Alzheimer's disease-associated protein in Alzheimer's disease frontal and temporal cortex. Archives of General Psychiatry, 48(11), 1009-1012.

Alterations in Alzheimer's disease-associated protein in Alzheimer's disease frontal and temporal cortex. / Bissette, Garth; Smith, Wayne H.; Dole, Kenneth C.; Crain, Barbara; Ghanbari, Hossein; Miller, Barney; Nemeroff, Charles.

In: Archives of General Psychiatry, Vol. 48, No. 11, 01.12.1991, p. 1009-1012.

Research output: Contribution to journalArticle

Bissette, G, Smith, WH, Dole, KC, Crain, B, Ghanbari, H, Miller, B & Nemeroff, C 1991, 'Alterations in Alzheimer's disease-associated protein in Alzheimer's disease frontal and temporal cortex', Archives of General Psychiatry, vol. 48, no. 11, pp. 1009-1012.
Bissette G, Smith WH, Dole KC, Crain B, Ghanbari H, Miller B et al. Alterations in Alzheimer's disease-associated protein in Alzheimer's disease frontal and temporal cortex. Archives of General Psychiatry. 1991 Dec 1;48(11):1009-1012.
Bissette, Garth ; Smith, Wayne H. ; Dole, Kenneth C. ; Crain, Barbara ; Ghanbari, Hossein ; Miller, Barney ; Nemeroff, Charles. / Alterations in Alzheimer's disease-associated protein in Alzheimer's disease frontal and temporal cortex. In: Archives of General Psychiatry. 1991 ; Vol. 48, No. 11. pp. 1009-1012.
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